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Table 1 Biological and biochemical characteristics of women diagnosed with benign ovarian lesion (BOL), high-grade serous ovarian carcinoma (HGSOC) and entire cohort (Total)

From: Pre-operative levels of angiopoietin protein-like 3 (ANGPTL3) in women diagnosed with high-grade serous carcinoma of the ovary

 

Women with BOL (n = 40)

Women with HGSOC (n = 31)

Total

P-value (unpaired)

P-value (paired)

AGE (years)

     

 Mean (SD)

63.7 (9.4)

64.8 (9.6)

64.2 (9.5)

  

 Median [IQR]

64.7 [57.7; 70.9]

64.8 [58.3; 70.7]

64.8 [58.0; 71.0]

0.65 a

0.13 d

POST-MENOPAUSAL STATUS

     

 Yes (%)

33 (80.4)

21 (91.3)

54 (76.1)

  

 No (%)

4 (9.8)

2 (6.7)

6 (8.4)

0.29 b

 

 Missing (%)

4 (9.8)

7 (23.3)

11 (15.5)

  

TUMOR STAGE

     

 I

–

3

3

  

 II

–

3

3

  

 III

–

21

21

  

 IV

–

4

4

  

TUMOR MARKERS

     

CA125 (U/mL)

     

 Mean (SD)

21 (12)

422 (1358)

196 (913)

  

 Median [IQR]

17 [12; 27]

54 [29; 301]

27 [14; 53]

1.4 E-7 c****

5.3 E-6 e****

HE4 (pmol/L)

     

 Mean (SD)

66 (25)

539 (1185)

244 (754)

  

 Median [IQR]

57 [49, 83]

155 [93; 447]

77 [54; 129]

2.2 E-7 c****

2.0 E-5 e****

 Missing

2 (5.0%)

8 (25.8%)

10 (14.1%)

  

LIPIDS

     

TG (mmol/L)

     

 Mean (SD)

1.45 (0.71)

1.46 (0.65)

1.45 (0.68)

  

 Median [IQR]

1.23 [0.95; 1.74]

1.34 [1.02; 1.63]

1.34 [0.99; 1.70]

0.87 c

0.92 d

Lp(a) (nmol/L)

     

 Mean (SD)

73.9 (88.0)

74.4 (98.0)

74.1 (91.8)

  

 Median [IQR]

34.5 [12; 106]

21.0 [7; 134]

28.0 [11; 111]

0.66 c

0.63 d

HDL (mmol/L)

     

 Mean (SD)

1.55 (0.46)

1.45 (0.33)

1.51 (0.41)

  

 Median [IQR]

1.48 [1.22; 1.76]

1.49 [1.15; 1.68]

1.49 [1.19; 1.73]

0.26 a

0.24 d

TC (mmol/L)

     

 Mean (SD)

5.35 (1.09)

5.39 (1.05)

5.37 (1.07)

  

 Median [IQR]

5.42 [4.41; 6.15]

5.16 [4.44; 6.26]

5.28 [4.43; 6.24]

0.93 c

0.96 d

Apo B (g/L)

     

 Mean (SD)

1.00 (0.23)

1.03 (0.26)

1.01 (0.24)

  

 Median [IQR]

0.99 [0.81; 1.16]

0.99 [0.85; 1.17]

0.99 [0.83; 1.16]

0.63 a

0.82 d

Non-HDL (mmol/L)

     

 Mean (SD)

3.79 (1.00)

3.94 (1.02)

3.86 (1.01)

  

 Median [IQR]

3.73 [2.91; 4.56]

3.77 [3.08; 4.76]

3.77 [3.01; 4.70]

0.55 a

0.72 d

LDL (mmol/L)

     

 Mean (SD)

3.13 (0.98)

3.28 (0.97)

3.20 (0.98)

  

 Median [IQR]

3.08 [2.38; 3.80]

3.17 [2.39; 3.98]

3.10 [2.38; 3.84]

0.54 a

0.69 d

LIPID-RELATED FACTORS

     

Apo CIII (μg/mL)

     

 Mean (SD)

526 (241)

615 (306)

569 (276)

  

 Median [IQR]

485 [404; 616]

562 [459; 826]

508 [404; 688]

0.15 c

0.33 d

 Missing

8 (20.0%)

1 (3.2%)

9 (12.7%)

  

ANGPTL3 (ng/mL)

     

 Mean (SD)

67 (31)

84 (29)

74 (31)

  

 Median [IQR]

65 [46; 86]

77 [66; 102]

70 [51; 92]

0.019 a *

0.030 d *

PCSK9 (ng/mL)

     

 Mean (SD)

108 (32)

103 (38)

106 (35)

  

 Median [IQR]

104 [87; 118]

97 [79; 113]

103 [82; 117]

0.33 c

0.44 d

  1. TG triglycerides, Lp(a) lipoprotein (a), TC total cholesterol, Apo B apolipoprotein B
  2. a Student T-test, b Fisher’s Exact Test for count data, c Wilcoxon Mann Whitney U test, d Paired Student T-test, e Paired Wilcoxon signed rank test
  3. Boldface indicates significance with *: P < 0.05, ****: P < 0.000 1
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Lipids in Health and Disease

ISSN: 1476-511X