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Table 3 Clinical characteristics of patients carrying the APOA5 mutation and others

From: The pathogenic mutations of APOA5 in Chinese patients with hyperlipidemic acute pancreatitis

 

group I (n = 52)

group II (n = 50)

group III (n = 61)

Pa

Pb

Pc

Age (years)

39.96 ± 8.40

39.98 ± 9.18

39.43 ± 11.54

0.992

0.782

0.784

Male, n (%)

41, 79%

39, 78%

52, 85%

0.917

0.374

0.323

Hospital stay (days)

9.65 ± 5.52

11.58 ± 10.23

10.26 ± 5.62

0.24

0.274

0.796

BMI (kg/m2)

27.44 ± 3.65

27.72 ± 3.17

27.60 ± 4.05

0.714

0.838

0.88

WBC (× 10ꝰ /L)

14.06 ± 3.78

14.25 ± 4.66

14.13 ± 4.14

0.968

0.933

0.902

CRP (mg/L)

153.94 ± 115.24

210.73 ± 111.22

194.64 ± 114.55

0.024*

0.06

0.506

BUN (mmol/L)

5.40 ± 5.39

7.39 ± 15.47

4.75 ± 2.00

0.438

0.519

0.831

Serum creatinine (μmol/L)

66.98 ± 18.05

71.73 ± 35.03

71.27 ± 26.54

0.94

0.534

0.604

Ca2+ (mmol/L)

2.05 ± 0.25

2.05 ± 0.24

2.07 ± 0.22

0.828

0.968

0.939

GLU (mmol/L)

9.29 ± 4.49

11.48 ± 4.87

11.20 ± 5.82

0.021*

0.057

0.518

TG (mmol/L)

15.33 ± 15.80

17.80 ± 19.20

20.55 ± 22.26

0.861

0.409

0.602

TC (mmol/L)

8.57 ± 4.92

9.17 ± 5.21

9.76 ± 5.63

0.542

0.239

0.673

Diabetes mellitus, n (%)

18, 35%

30, 60%

39, 64%

0.01*

0.002**

0.671

Hypertension, n (%)

13, 25%

11, 22%

12, 20%

0.721

0.496

0.763

Fatty liver, n (%)

43, 83%

45, 90%

50, 82%

0.284

0.92

0.231

ARDS, number, n (%)

2, 4%

6, 12%

2, 3%

0.156

1.000

0.137

SAP number, n (%)

2, 4%

6, 12%

2, 3%

0.156

1.000

0.137

MSAP & SAP number, n (%)

29, 56%

26, 52%

28, 46%

0.703

0.296

0.522

CTSI > 4 score number, n (%)

18, 35%

26, 52%

28, 46%

0.076

0.224

0.522

Recurrence, n (%)

32, 62%

26, 52%

30, 49%

0.331

0.188

0.768

Repeated recurrence, n (%)

24, 46%

13, 26%

23, 38%

0.034*

0.364

0.19

  1. Group I: patients with HLAP harboring pathogenic mutations in APOA5, group II: patients with HLAP harboring pathogenic mutations in 25 genes from PLA2G6 to TIMD4, group III: the remaining HLAP patients
  2. BMI body mass index, WBC white blood cells, CRP C-reactive protein, BUN blood urea nitrogen, Ca2+ serum calcium, GLU blood glucose, TG serum triglyceride, TC serum cholesterol, ARDS acute respiratory distress syndrome, MSAP moderately severe acute pancreatitis, SAP severe acute pancreatitis, CTSI computed tomography severity index, Repeated recurrence: at least two episodes of recurrence in one patient
  3. *P < 0.05
  4. **P < 0.05
  5. aP value of group I compared with group II
  6. bP value of group I compared with group III, and
  7. cP value of group II compared with group III.