Adipokines in atopic dermatitis: the link between obesity and atopic dermatitis

Zhang, Shiyun; Zhang, Bingjie; Liu, Yuehua; Li, Li

doi:10.1186/s12944-024-02009-z

Lipids in Health and Disease

Table 1 Results of existing studies concerning the changes of adipokines in AD patients

From: Adipokines in atopic dermatitis: the link between obesity and atopic dermatitis

Adipokine	Study	Subjects	Sample size		Change In AD	Relationship With Severity of AD^a	Correlation With IgE
Adipokine	Study	Subjects	Patients with AD	Control	Change In AD	Relationship With Severity of AD^a	Correlation With IgE
Leptin	Jung MJ et al., Korea, 2020 [20]	Adults	40	6	Increase in circulation	No correlation (EASI)	Positive
	Kimata H, Japan, 2002 [54]	Children	25	25	Increase in circulation	UN	Positive
	Jaworek AK et al., Poland, 2020 [55]	Adults	49	30	Increase in circulation	No difference between mild and severe eczema^b	No correlation
	Kimata H, Japan, 2004 [56]	Lactating women	30	30	Decrease in circulation	UN	UN
	Balato N et al., Italy, 2011 [57]	Teenagers^e and adults	5	117	Decrease in circulation	UN	UN
	Bostanci I et al,. Turkey, 2004 [60]	Children	20	20	No difference	UN	UN
	Seo S et al., Korea, 2016 [58]	Children	59	31	Decrease in circulation	No correlation (SCORD); mild group higher than severe group^c	UN
	Han B et al., Korea 2016 [59]	Children and adults	64	UN	UN	No correlation (EASI)	UN
	Banihani SA et al., Jordan, 2018 [61]	Children and adults	164	167	UN	UN	UN
Adiponectin	Jung MJ et al., Korea, 2020 [20]	Adults	40	6	Decrease in circulation	No correlation (EASI)	No correlation
	Jaworek AK et al., Poland, 2020 [55]	Adults	49	30	Decrease in circulation	No difference between mild and severe eczema^b	No correlation
	Seo S et al., Korea, 2016 [58]	Children	59	31	No difference	No correlation (SCORD); No difference between mild and severe group^c	UN
	Han B et al., Korea 2016 [59]	Children and adults	64	UN	UN	No correlation (EASI)	UN
	Al-Shaheri F et al., Jordan, 2022 [76]	Children and adults	162	162	Decrease in circulation	UN	UN
	Lee SH et al., Korea, 2022 [77]	Adults	75	28	Decrease in circulation	Negative (EASI)	No correlation
	Nagel G et al., Germany, 2009 [78]	Children	50	338	UN	UN	UN
	Seo HS et al., Korea, 2019 [79]	In vitro epidermal equivalent model	UN	UN	UN	UN	UN
Resistin	Jaworek AK et al., Poland, 2020 [55]	Adults	49	30	Decrease in circulation	Negative (SCORAD)	Negative
	Banihani SA et al., Jordan, 2018 [97]	Children and adults	162	161	Decrease in circulation	UN	UN
	Farag AGA et al., Egypt, 2020 [98]	Children and adults	45	40	Decrease in circulation	Negative (SCORAD)	UN
	Machura E et al., Poland, 2013 [99]	Children	27	46	Increase in circulation	UN	UN
Visfatin	Suga H et al., Japan, 2013 [104]	Adults	40	42	Increase in circulation	No difference between mild, moderate and severe eczema^d	UN
Visfatin	Machura E et al., Poland, 2013 [99]	Children	27	46	Decrease in circulation	UN	UN
DPP4	Miyagaki T et al., Japan, 2013 [109]	Adults	32	27	No difference	No correlation (Rajka Langeland severity score)	No correlation
DPP4	Tasic T et al., Germany, 2011 [110]	Skin biopsies and rats	UN	UN	UN	UN	UN
FABP4	Brunner PM et al., USA, 2019 [112]	Children and adults	88	37	Increase in circulation^g	UN	UN
FABP5	Takahashi-Shishido N et al., Japan, 2021 [113]	Skin biopsies	12	8	Increase in skin	UN	UN
FABP5	Yamane Y et al., Japan, 2009 [114]	Horny layer samples	36	16	Increase in circulation skin	Positive (local severity score^h)	UN
Apelin	Machura E et al., Poland, 2013 [99]	Children	27	46	Increase in circulation	UN	UN
ZAG	Noh JY et al., Korea, 2019 [120]	Patients with AD^f, skin biopsies and rats	90	36	Decrease in circulation	No correlation (EASI)	UN

Abbreviations: AD Atopic dermatitis, DPP4 Dipeptidyl peptidase-4, EASI Eczema Area and Severity Index, FABP Fatty acid binding protein, IgE Immunoglobulin E, SCORAD SCORing Atopic Dermatitis index, UN Unmentioned, ZAG Zinc-α2-glycoprotein
^aIn correlation analysis, severity of AD was quantified by different methods given in parentheses
^bmild: SCORAD < 25; severe: SCORAD > 50
^cmild: SCORAD < 40; severe: SCORAD ≥ 40
^didentified by Rajka Langeland severity score
^eTeenagers are defined as minors older than 14
^fAges of AD patients are not noted
^gonly children show significant increase of FABP4 in AD
^hLocal severity score of a measured lesion was presented by the sum of the respective severity scores (0–24) based on the modified scoring scale of each eruption shown in the SCORAD index and clinical features shown by Leung

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