Table 5 Interaction analyses of Lp-PLA2 activity with CV death and MACE occurrence across different subgroups

Lp-PLA₂ (as a dichotomous variable)

Sex

0.247

0.385

 Male

43/223

1.68(0.91–3.11)

0.096

2.06(1.04–4.08)

0.038

 Female

34/138

3.01(1.36–6.67)

0.007

3.95(1.68–9.23)

0.002

Age

0.329

0.53

  ≥ 60

57/198

2.24(1.29–3.89)

0.004

2.65(1.49–4.69)

0.001

  < 60

20/163

2.21(0.85–5.75)

0.105

2.70(0.91–7.99)

0.074

History of diabetes

0.313

0.205

 Yes

27/86

3.06(1.34–7.02)

0.008

3.99(1.67–9.54)

0.002

 No

50/275

1.87(1.04–3.35)

0.037

2.21(1.20–4.06)

0.011

History of CAD

0.399

0.774

 Yes

15/37

3.27(1.16–9.23)

0.025

2.05(0.65–6.50)

0.221

 No

62/324

2.26(1.31–3.92)

0.004

2.70(1.54–4.73)

0.001

LDL-c (mmol/L)

0.821

0.733

  ≥ 2.45

36/181

2.44(1.01–5.86)

0.046

2.68(1.06–6.78)

0.037

  < 2.45

41/180

2.74(1.48–5.07)

0.001

3.81(1.88–7.71)

 < 0.001

HDL-c (mmol/L)

0.771

0.470

  ≥ 1.03

39/184

1.98(1.03–3.81)

0.04

2.04(1.02–4.09)

0.045

  < 1.03

38/177

2.30(1.14–4.63)

0.02

3.50(1.65–7.44)

0.001

TG (mmol/L)

0.745

0.576

  ≥ 1.29

39/182

2.39(1.14–5.05)

0.022

3.30(1.48–7.37)

0.004

  < 1.29

38/179

2.03(1.06–3.86)

0.032

2.43(1.25–4.74)

0.009

Lp-PLA₂ (as a continuous variable)(per 100U/L)

Sex

0.169

0.25

 Male

43/223

1.09(0.93–1.28)

0.271

1.20(0.99–1.46)

0.064

 Female

34/138

1.29(1.09–1.52)

0.003

1.33(1.12–1.59)

0.002

Age

0.854

0.712

  ≥ 60

57/198

1.19(1.04–1.35)

0.1

1.22(1.06–1.40)

0.006

  < 60

20/163

1.21(0.97–1.53)

0.096

1.28(0.99–1.65)

0.053

History of diabetes

0.11

0.086

 Yes

27/86

1.47(1.13–1.90)

0.004

1.53(1.17–2.01)

0.002

 No

50/275

1.16(1.01–1.33)

0.041

1.21(1.04–1.41)

0.015

History of CAD

0.379

0.688

 Yes

15/37

1.31(0.99–1.74)

0.059

1.09(0.73–1.64)

0.667

 No

62/324

1.19(1.06–1.35)

0.007

1.27(1.11–1.46)

0.001

LDL-c (mmol/L)

0.317

0.061

  ≥ 2.45

36/181

1.15(0.96–1.38)

0.116

1.16(0.95–1.42)

0.135

  < 2.45

41/180

1.30(1.12–1.52)

0.001

1.62(1.29–2.04)

 < 0.001

HDL-c (mmol/L)

0.923

0.122

  ≥ 1.03

39/184

1.17(1.00–1.37)

0.047

1.21(1.01–1.46)

0.043

  < 1.03

38/177

1.20(1.01–1.41)

0.041

1.33(1.11–1.60)

0.002

TG (mmol/L)

0.574

0.879

  ≥ 1.29

39/182

1.17(1.00–1.36)

0.048

1.25(1.05–1.49)

0.011

  < 1.29

38/179

1.25(1.03–1.52)

0.026

1.35(1.08–1.68)

0.008

MACEs

Events/Total

Unadjusted

P for Interaction

Adjusted

P for Interaction

HR (95% CI)

P

HR (95% CI)

P

Lp-PLA₂ (as a dichotomous variable)

Sex

0.105

0.311

 Male

51/223

1.35(0.78–2.35)

0.285

1.72(0.93–3.18)

0.087

 Female

37/138

2.91(1.37–6.17)

0.005

3.99(1.78–8.94)

0.001

Age

0.595

0.246

  ≥ 60

67/198

1.80(1.10–2.95)

0.019

2.10(1.26–3.49)

0.004

  < 60

21/163

2.39(0.93–6.15)

0.072

3.10(1.02–9.41)

0.047

History of diabetes

0.352

0.282

 Yes

29/86

2.50(1.16–5.40)

0.019

2.77(1.25–6.13)

0.012

 No

59/275

1.64(0.97–2.77)

0.068

1.97(1.14–3.41)

0.016

History of CAD

0.332

0.914

 Yes

16/37

2.81(1.03–7.62)

0.043

1.86(0.54–6.43)

0.325

 No

72/324

1.88(1.15–3.07)

0.012

2.25(1.35–3.75)

0.002

LDL-c (mmol/L)

0.965

0.993

  ≥ 2.45

42/181

2.14(0.99–4.61)

0.054

2.39(1.05–5.44)

0.039

  < 2.45

46/180

2.18(1.22–3.88)

0.008

2.59(1.36–4.95)

0.004

HDL-c (mmol/L)

0.792

0.540

  ≥ 1.03

43/184

1.71(0.93–3.15)

0.087

1.72(0.90–3.29)

0.102

  < 1.03

45/177

1.93(1.04–3.59)

0.038

2.77(1.41–5.46)

0.033

TG (mmol/L)

0.956

0.739

  ≥ 1.29

46/182

1.85(0.98–3.52)

0.059

2.38(1.19–4.76)

0.014

  < 1.29

42/179

1.80(0.98–3.30)

0.059

1.95(1.02–3.75)

0.044

Lp-PLA₂ (as a continuous variable)(per 100U/L)

Sex

0.055

0.409

 Male

51/223

1.03(0.89–1.20)

0.692

1.12(0.93–1.34)

0.24

 Female

37/138

1.28(1.09–1.51)

0.002

1.35(1.13–1.61)

 < 0.001

Age

0.343

0.804

  ≥ 60

67/198

1.12(0.99–1.27)

0.065

1.15(1.01–1.32)

0.04

  < 60

21/163

1.27(1.01–1.59)

0.038

1.37(1.03–1.81)

0.028

History of diabetes

0.238

0.189

 Yes

29/86

1.33(1.04–1.71)

0.022

1.35(1.04–1.75)

0.023

 No

59/275

1.12(0.99–1.28)

0.073

1.17(1.02–1.35)

0.03

History of CAD

0.386

0.831

 Yes

16/37

1.26(0.96–1.66)

0.096

1.15(0.79–1.68)

0.473

 No

72/324

1.15(1.02–1.29)

0.026

1.26(1.07–1.40)

0.003

LDL-c (mmol/L)

0.398

0.246

  ≥ 2.45

42/181

1.12(0.95–1.33)

0.170

1.16(0.97–1.40)

0.106

  < 2.45

46/180

1.24(1.07–1.44)

0.006

1.40(1.12–1.74)

0.003

HDL-c (mmol/L)

0.906

0.880

  ≥ 1.03

43/184

1.13(0.97–1.31)

0.114

1.15(0.97–1.36)

0.118

  < 1.03

45/177

1.15(0.98–1.34)

0.079

1.27(1.07–1.51)

0.008

TG (mmol/L)

0.587

0.929

  ≥ 1.29

46.182

1.12(0.97–1.29)

0.117

1.21(1.03–1.42)

0.018

  < 1.29

42/179

1.19(0.99–1.44)

0.066

1.22(0.99–1.50)

0.061