Table 1 Baseline demographic, clinical, and biochemical characteristics of the study population
|  | All Patients (n = 361) | Low Lp-PLA2 (< 481.2U/L; n = 181) | High Lp-PLA2 (> 481.2U/L; n = 180) | P |
|---|---|---|---|---|
Age(years) | 61 (53,70) | 62 (52,70) | 60 (53,69) | 0.474 |
Dialysis vintage(months) | 35.5(17.8,76.2) | 32.4(17.1,69.5) | 37.5(20.1,79.7) | 0.217 |
Gender, male (%) | 223 (61.8) | 121 (66.9) | 102 (56.7) | 0.046 |
Body mass index(kg/m2) | 22.13 ± 3.50 | 22.02 ± 3.26 | 22.23 ± 3.74 | 0.578 |
Smoking history (%) | 31 (8.6) | 11 (6.1) | 20(11.1) | 0.088 |
Access (AVF), (%) | 250 (69.3) | 119 (65.7) | 131(72.8) | 0.148 |
Underlying kidney disease (%) | Â | Â | Â | 0.945 |
 Chronic Glomerulonephritis | 174(48.2) | 87(48.1) | 87(48.3) |  |
 Diabetic nephropathy | 41(11.4) | 19(10.5) | 22(12.2) |  |
 Hypertensive nephropathy | 49(13.6) | 27(14.9) | 22(12.2) |  |
 Polycystic kidney disease | 20(5.5) | 11(6.1) | 9(5.0) |  |
 Others | 14(3.9) | 6(3.3) | 8(4.4) |  |
 Unknown | 63(17.5) | 31(17.1) | 32(17.8) |  |
Comorbidity (%) | ||||
 Hypertension | 337(93.4) | 169(93.4) | 168(93.3) | 0.989 |
 Diabetes | 86(23.8) | 45(24.9) | 41(22.8) | 0.642 |
 Coronary artery disease | 37(10.2) | 24(13.3) | 13(7.2) | 0.059 |
 Cerebrovascular event | 41(11.4) | 22(12.2) | 19(10.6) | 0.632 |
Medications (%) | ||||
 ACEI | 73(20.2) | 34(18.8) | 39(21.7) | 0.495 |
 ARB | 127(35.2) | 59(32.6) | 68(37.8) | 0.303 |
 CCB | 268(74.2) | 135(74.6) | 133(73.9) | 0.880 |
 β-blockers | 153(42.4) | 78(43.1) | 75(41.7) | 0.784 |
 Statin | 66(18.3) | 42(23.2) | 24(13.3) | 0.015 |
 Aspirin | 103(28.5) | 48(26.5) | 55(30.6) | 0.396 |
Laboratory parameters | ||||
 Hemoglobin(g/L) | 111.25 ± 15.8 | 110.6 ± 16.6 | 111.9 ± 14.9 | 0.459 |
 Platelet(× 109/L) | 190.2 ± 69.5 | 192.8 ± 68.9 | 187.7 ± 70.1 | 0.490 |
 White blood cell(× 109/L) | 6.46 ± 1.82 | 6.44 ± 1.73 | 6.48 ± 1.90 | 0.836 |
 Neutrophil(× 109/L) | 4.31 ± 1.47 | 4.29 ± 1.38 | 4.33 ± 1.56 | 0.784 |
 Lymphocyte(× 109/L) | 1.3(1.0,1.6) | 1.3(1.0,1.6) | 1.3(1.0,1.6) | 0.752 |
 Albumin(g/L) | 38.63 ± 3.18 | 38.60 ± 3.28 | 38.66 ± 3.10 | 0.874 |
 Pre-albumin(g/L) | 0.28 ± 0.08 | 0.27 ± 0.09 | 0.29 ± 0.08 | 0.005 |
 Urea(mmol/L) | 24.6 ± 6.7 | 24.2 ± 6.6 | 25.1 ± 6.7 | 0.207 |
 Creatinine(μmol/L) | 1040.2 ± 301.2 | 1025.7 ± 296.1 | 1054.9 ± 306.4 | 0.357 |
 Uric acid(mmol/L) | 429.8 ± 79.5 | 429.8 ± 78.0 | 429.8 ± 81.2 | 0.995 |
 Total cholesterol (mmol/L) | 4.43 ± 1.12 | 3.98 ± 0.90 | 4.89 ± 1.14 |  < 0.001 |
 LDL-c(mmol/L) | 2.64 ± 0.99 | 2.23 ± 0.74 | 3.06 ± 1.05 |  < 0.001 |
 HDL-c (mmol/L) | 1.08 ± 0.33 | 1.09 ± 0.34 | 1.08 ± 0.33 | 0.700 |
 Apo-B(g/L) | 0.85 ± 0.24 | 0.75 ± 0.19 | 0.95 ± 0.24 |  < 0.001 |
 Apo-A(g/L) | 1.25 ± 0.27 | 1.25 ± 0.27 | 1.25 ± 0.27 | 0.856 |
 Triglyceride(mmol/L) | 1.55 ± 1.21 | 1.46 ± 1.10 | 1.64 ± 1.31 | 0.160 |
 Homocysteine(μmol/L) | 32.2(23.8,50.5) | 29.8(22.5,51.9) | 34.0(24.4,49.0) | 0.374 |
 Lp(a) (nmol/L) | 202.0(105.0,366.5) | 176.2(105.4,354.9) | 208.5(103.2,398.0) | 0.395 |
 NT-proBNP(pg/ml) | 3550(1857,7271) | 3513(1789,7390) | 3564(1896,7181) | 0.860 |
 Troponin T(ng/ml) | 0.05(0.03,0.08) | 0.046(0.032,0.079) | 0.05(0.034,0.076) | 0.498 |
 hs-CRP (mg/L) | 2.9(1.1,6.4) | 2.64(1.03,6.78) | 3.22(1.20,6.08) | 0.590 |