Table 3 Oxylipins composition of maternal breast milk according to the 4 groups

Isoprostanes

5(RS)-5-F_2c-IsoP

0.09 ± 0.02

0.10 ± 0.02

0.12 ± 0.02

0.11 ± 0.02

0.57

5-epi-5-F_2t-IsoP

0.09 ± 0.01

0.09 ± 0.01

0.08 ± 0.01

0.11 ± 0.01

0.76

5-F_2t-IsoP

0.04 ± 0.02

0.06 ± 0.02

0.07 ± 0.02

0.06 ± 0.02

0.57

Lipoxin

 15(R)-Lipoxin A4

0.03 ± 0.006

0.02 ± 0.007

0.02 ± 0.007

0.04 ± 0.006

0.30

Prostaglandins

 PGF_2α

1.87 ± 0.44^a

0.31 ± 0.47^ab

0.22 ± 0.49^ab

0.21 ± 0.45^b

0.03

 PGE₂

1.28 ± 0.25^a

0.52 ± 0.27^ab

0.31 ± 0.28^ab

0.33 ± 0.26^b

0.04

Oxidation or enzymatic oxidation products of DHA

 4(S)-HDHA

0.10 ± 0.04^a

0.19 ± 0.04^a

0.18 ± 0.05^a

0.59 ± 0.04^b

< 0.0001

 7(S)-HDHA

0.08 ± 0.02^a

0.09 ± 0.03^a

0.12 ± 0.03^a

0.38 ± 0.03^b

< 0.0001

 8(S)-HDHA

0.10 ± 0.05^a

0.17 ± 0.049^a

0.16 ± 0.05^a

0.68 ± 0.05^b

< 0.0001

 10(S)-HDHA

0.07 ± 0.02^a

0.07 ± 0.02^a

0.08 ± 0.02^a

0.32 ± 0.02^b

< 0.0001

 11(S)-HDHA

0.12 ± 0.06^a

0.12 ± 0.07^a

0.23 ± 0.07^a

0.69 ± 0.06^b

< 0.0001

 13(S)-HDHA

0.10 ± 0.04^a

0.10 ± 0.04^a

0.11 ± 0.04^a

0.49 ± 0.04^b

< 0.0001

 14(S)-HDHA

0.10 ± 0.05^a

0.13 ± 0.05^a

0.14 ± 0.05^a

0.67 ± 0.05^b

< 0.0001

 16(S)-HDHA

0.07 ± 0.03^a

0.10 ± 0.03^a

0.11 ± 0.04^a

0.42 ± 0.03^b

< 0.0001

 17(S)-HDHA

0.17 ± 0.17^a

0.19 ± 0.18^a

0.23 ± 0.19^a

1.37 ± 0.17^b

< 0.0001

 20(S)-HDHA

0.17 ± 0.07^a

0.23 ± 0.07^a

0.25 ± 0.07^a

0.96 ± 0.07^b

< 0.0001

Oxidation or enzymatic oxidation products of EPA

 18-HEPE

0.05 ± 0.01^a

0.06 ± 0.01^a

0.05 ± 0.01^a

0.11 ± 0.01^b

0.0001

Sum

 ∑HDHA

1.09 ± 0.44^a

1.39 ± 0.46^a

1.60 ± 0.49^a

6.56 ± 0.44^b

< 0.0001

 ∑Isoprostanes

0.22 ± 0.03

0.26 ± 0.04

0.28 ± 0.04

0.27 ± 0.03

0.66

 ∑Prostaglandins

3.15 ± 0.66^a

0.83 ± 0.70^ab

0.53 ± 0.74^b

0.54 ± 0.67^b

0.03