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Table 2 Fatty acid (FA) composition of maternal breast milk according to the 4 groups

From: Docosahexaenoic acid-rich algae oil supplementation in mothers of preterm infants is associated with a modification in breast milk oxylipins profile

 

Mean ± SD

 

Fatty acids

PL-Low

PL-High

S-DHA-Low

S-DHA-High

P -value 1

 

g/100 g of total fatty acid

n-6 FA

     

 18:2 n-6 (LA)

13.5 ± 0.90

13.2 ± 0.94

12.1 ± 1.00

13.7 ± 0.91

0.68

 18:3 n-6 (ALA)

0.11 ± 0.02

0.07 ± 0.02

0.09 ± 0.02

0.09 ± 0.02

0.56

 20:4 n-6 (AA)

0.52 ± 0.04

0.60 ± 0.04

0.48 ± 0.04

0.61 ± 0.04

0.08

 22:5 n-6 (n-6 DPA)

0.03 ± 0.02a

0.06 ± 0.02a

0.08 ± 0.02a

0.41 ± 0.02b

< 0.0001

n-3 FA

     

 18:3 n-3

1.44 ± 0.17

1.61 ± 0.18

1.65 ± 0.19

1.33 ± 0.18

0.63

 20:5 n-3 (EPA)

0.04 ± 0.02a

0.11 ± 0.02b

0.06 ± 0.02ab

0.10 ± 0.02b

0.01

 22:5 n-3 (n-3 DPA)

0.13 ± 0.01a

0.22 ± 0.01b

0.13 ± 0.01ac

0.18 ± 0.01bc

< 0.0001

 22:6 n-3 (DHA)

0.21 ± 0.05a

0.50 ± 0.05b

0.39 ± 0.06ab

1.46 ± 0.05c

< 0.0001

Ratios

     

 DHA:AA

0.40 ± 0.10a

0.91 ± 0.11b

0.89 ± 0.11b

2.40 ± 0.10c

< 0.0001

 n-3:n-6

0.14 ± 0.01a

0.18 ± 0.02ab

0.19 ± 0.02ab

0.22 ± 0.01b

0.01

Sums

     

 ∑saturated

45.0 ± 1.88

44.1 ± 1.98

43.8 ± 2.10

42.3 ± 1.90

0.78

 ∑MUFA

37.2 ± 1.71

38.0 ± 1.80

39.8 ± 1.91

38.2 ± 1.73

0.77

 ∑PUFA n-6

15.5 ± 0.93

15.0 ± 0.98

13.7 ± 1.04

16.0 ± 0.94

0.45

 ∑PUFA n-3

2.18 ± 0.21a

2.74 ± 0.23ac

2.56 ± 0.24a

3.41 ± 0.22bc

0.002

  1. LA: linoleic acid, AA: arachidonic acid, DPA: docosapentaenoic acid, ALA: alpha-linolenic acid, EPA: eicosapentaenoic acid, DHA: docosahexaenoic acid, MUFA: monounsaturated fatty acid, PUFA: polyunsaturated fatty acid
  2. 1Estimated using multivariate linear regression models adjusted for neonatal sex, gestational age, birth weight and multiple comparisons with Tukey-Kramer
  3. a–cMeans within a row with different superscripts are significantly different (P00.05)