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Table 1 Comparation of clinical parameters and neurophysiological test results between Control and DPN group

From: The mediating role of HbA1c in the association between elevated low-density lipoprotein cholesterol levels and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus

 

Control group (n = 55)

DPN group (n = 65)

P

Age (years)

58 (51–64)

57 (51.5–67)

0.666b

Female (n, %)

20, 36.36

24, 36.92

0.949c

High (cm)

169 (160–172)

167 (160.5-173.5)

0.870

Weight (kg)

70 (60-77.5)

69 (60.25–81.5)

0.802

BMI (kg /m2)

24.62 (22.66–26.54)

24.88 (21.91–27.84)

0.796b

Duration of DM (years)

8 (3–12)

10 (1-18.5)

0.346b

Duration of Hypertension (years)

0.00 (0.00–10.00)

0.00 (0.00-9.50)

0.963b

FPG (mmol/l)

8.92 ± 3.08

10.21 ± 4.02

0.054a

FCP (nmol/l)

0.40 (0.24–0.55)

0.27 (0.17–0.47)

0.058b

HOMA-IR

2.62 (2.17–3.35)

2.41 (2.12–3.27)

0.464b

HbA1c (%)

9.0 (7.3–10)

10.3 (8.85–12.2)

0.001b*

TG (mmol/l)

1.77 (1.25–2.45)

1.67 (1.10–2.54)

0.431b

TC (mmol/l)

4.51 (3.7–5.02)

4.62 (4.01–5.35)

0.111b

HDL-C (mmol/l)

0.85 (0.68–1.06)

0.87 (0.69–1.13)

0.484b

LDL-C (mmol/l)

2.34 ± 0.87

2.68 ± 0.98

0.052a

Statin (n, %)

25, 45.45

32, 49.23

0.680c

Other lipid-lowering drugs (n, %)

4, 7.27

6, 9.23

0.699c

Motor conduction

Ulnar nerve (m/s)

61.20 (59–63)

54.40 (51.35–59.80)

0.000b*

Radial nerve (m/s)

64.60 (62.55–66.20)

62.50 (60.85–64.62)

0.001b*

Median nerve (m/s)

60.00 (55.65–62.15)

53.50 (49.75–56.03)

0.000b*

Tibial nerve (m/s)

47.28 ± 3.17

41.00 ± 3.63

0.000a*

Common peroneal nerve (m/s)

46.75 (44.85–48.50)

42.15 (38.88–44.55)

0.000b*

Sensory conduction

Ulnar nerve (m/s)

55.94 ± 4.79

48.72 ± 5.90

0.000a*

Radial nerve (m/s)

57.17 ± 8.27

50.71 ± 6.67

0.000a*

Median nerve (m/s)

56.83 ± 5.61

45.47 ± 7.60

0.000a*

Sural nerve (m/s)

52.05 ± 4.96

44.68 ± 5.39

0.000a*

  1. The data are presented as n (%), or the median (inter-quartile range) unless otherwise specified
  2. a Student’s t test was employed for normally distributed variables
  3. b The Mann-Whitney U test was employed for asymmetrically distributed variables
  4. c The Chi-square test was employed for categorical variables
  5. *P < 0.05
  6. Abbreviations: DPN, diabetic peripheral neuropathy; BMI, body mass index; DM, diabetes mellitus; FPG, fasting plasma glucose; HbA1c, glycosylated hemoglobin; FCP, fasting C-peptide; TG, triglycerides; TC, total cholesterol; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol