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Fig. 6 | Lipids in Health and Disease

Fig. 6

From: Brain region–specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer’s disease

Fig. 6

Phospholipid profiles of the PLBWT and PLB4 cortex, hippocampus, and hypothalamus. Each lipid class (sum of all species) is represented as an average percentage (± SEM) of the corresponding PLBWT class, n = 6. A Wilcoxon signed-rank test was performed to determine statistically significant differences between PLBWT and PLB4 data, where * denotes P ≤ 0.05. Cortex: PE PLBWT vs. PLB4: P = 0.0313; DG PLBWT vs. PLB4: P = 0.0313; TG PLBWT vs. PLB4: p = 0.0313. Hippocampus: PC PLBWT vs. PLB4: P = 0.0313; TG PLBWT vs. PLB4: P = 0.0313. Hypothalamus: TG PLBWT vs. PLB4: P = 0.0313. Abbreviations: PE – phosphatidylethanolamine, PS – phosphatidylserine, PI – phosphatidylinositol, PC – phosphatidylcholine, CER – ceramide, DG – diacylglycerol, TG – triacylglycerol, PA – phosphatidic acid, SM – sphingomyelin, PG – phosphatidylglycerol

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