Bee pollen and propolis improve neuroinflammation and dysbiosis induced by propionic acid, a short chain fatty acid in a rodent model of autism

Table 3 ROC-Curve of various parameters in all groups

Parameters	Groups	AUC	Cut-off value	Sensitivity %	Specificity %	P value	95% CI
IFN-γ (pg/ml)	PPA	0.500	25.380	50.0%	66.7%	1.000	0.153–0.847
	Bee pollen	0.889	8.445	83.3%	100.0%	0.025	0.673–1.105
	Propolis	0.667	17.380	83.3%	66.7%	0.337	0.331–1.002
IL-1A (pg/ml)	PPA	0.694	172.545	66.7%	66.7%	0.262	0.385–1.004
	Bee pollen	0.861	129.458	66.7%	100.0%	0.037	0.645–1.077
	Propolis	0.569	152.360	83.3%	50.0%	0.689	0.210–0.928
IL-6 (pg/ml)	PPA	0.833	23.195	83.3%	83.3%	0.055	0.570–1.096
	Bee pollen	0.667	16.880	66.7%	83.3%	0.337	0.317–1.017
	Propolis	0.583	18.145	66.7%	66.7%	0.631	0.241–0.926
IL-10 (PG/ML)	PPA	0.917	122.270	100.0%	83.3%	0.016	0.742–1.091
	Bee pollen	0.889	119.215	100.0%	83.3%	0.025	0.673–1.105
	Propolis	0.597	122.055	66.7%	83.3%	0.575	0.239–0.956
IL-12 (P70) (pg/ml)	PPA	0.833	72.835	66.7%	100.0%	0.055	0.593–1.073
	Bee pollen	0.861	72.130	83.3%	100.0%	0.037	0.604–1.119
	Propolis	0.903	72.130	83.3%	100.0%	0.020	0.708–1.098
VEGF (pg/ml)	PPA	0.597	4.500	66.7%	66.7%	0.575	0.253–0.941
	Bee pollen	0.889	4.240	83.3%	83.3%	0.025	0.697–1.081
	Propolis	0.944	3.645	83.3%	100.0%	0.010	0.814–1.075
TNFα (pg/ml)	PPA	0.944	15.095	83.3%	100.0%	0.010	0.814–1.075
	Bee pollen	0.833	14.845	83.3%	100.0%	0.055	0.535–1.132
	Propolis	1.000	14.680	100.0%	100.0%	0.004	1.000–1.000

ROC, receiver operating characteristics curve; AUC, area under the curve; IFN-γ, interferon γ

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