Table 2 Estimation of the effects of CoQ10 supplementation on lipid profiles at baseline and the end of the treatment between intervention and placebo groups
Variable | Number of study | Standardized Mean difference | CI 95% | P-value | Heterogeneity | |||
|---|---|---|---|---|---|---|---|---|
I2 (%) | Q | P-value Heterogeneity | ||||||
TC | Intervention group (after vs. before) | 7 | -1.07 | −1.88, − 0.26 | 0.009 | 93.7 | 95.40 | < 0.001 |
Placebo group (after vs. before) | 7 | −0.37 | − 0.56, − 0.19 | < 0.001 | 42.0 | 10.34 | 0.11 | |
Change intervention group vs. placebo group | 8 | −1.07 | −1.94, − 0.21 | 0.015 | 94.9 | 138.32 | < 0.001 | |
LDL-C | Intervention group (after vs. before) | 5 | −0.71 | −1.30, − 0.12 | 0.019 | 84.8 | 26.27 | < 0.001 |
Placebo group (after vs. before) | 5 | −0.55 | −1.21, 0.10 | 0.098 | 87.3 | 31.60 | < 0.001 | |
Change intervention group vs. placebo group | 6 | −0.37 | −0.87, 0.13 | 0.149 | 82.8 | 29.05 | < 0.001 | |
TG | Intervention group (after vs. before) | 3 | 0.15 | −0.38, 0.68 | 0.591 | 71.6 | 7.04 | 0.03 |
Placebo group (after vs. before) | 3 | −0.09 | −0.34, 0.17 | 0.493 | 0.00 | 0.31 | 0.85 | |
Change intervention group vs. placebo group | 4 | 0.01 | −0.22, 0.24 | 0.940 | 0.00 | 2.93 | 0.40 | |
HDL-C | Intervention group (after vs. before) | 4 | 0.54 | −0.07, 1.16 | 0.081 | 82.3 | 16.93 | 0.001 |
Placebo group (after vs. before) | 4 | −0.01 | − 0.24, 0.23 | 0.964 | 0.00 | 0.35 | 0.95 | |
Change intervention group vs. placebo group | 5 | 1.30 | 0.20, 2.41 | 0.021 | 94.7 | 76.05 | < 0.001 | |
Lp(a) | Intervention group (after vs. before) | 2 | − 0.71 | − 1.91, 0.50 | 0.252 | 89.1 | 9.19 | 0.002 |
Placebo group (after vs. before) | 2 | 0.02 | −0.37, 0.40 | 0.929 | 0.00 | 0.17 | 0.68 | |
Change intervention group vs. placebo group | 3 | −1.12 | −2.84, 0.61 | 0.204 | 95.7 | 46.96 | < 0.001 | |