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Table 3 Mendelian randomization analyses of maternal hip circumference and birth size and puberty height

From: Maternal central obesity and birth size: a Mendelian randomization analysis

Outcomes

Consortium

Maternal HIPadjBMI (value of 1 SD with units, GIANT)

Main analysis

Sensitivity analysis

IVW

Weighted-median

MR-Egger

β (95% CI)

P-value

β (95% CI)

P-value

β (95% CI)

P-value

Intercept (95% CI)

P-value

Birth length(SD), cm

 Birth length

EGG

0.392(0.258 to 0.526)

1.12 × 10−06

0.433 (0.291 to 0.574)

2.2 × 10−09

0.798 (0.247 to 1.349)

0.005

−0.015 (− 0.036 to 0.005)

0.136

Birth weight(SD), kg

 Birth weight

EGG

0.168 (0.093 to 0.242)

7.1 × 10−05

0.175 (0.108 to 0.241)

2.5 × 10−07

0.153 (− 0.157 to 0.464)

0.332

0.001 (−0.011 to 0.012)

0.972

Head circumference (HC)(SD), cm

 HC

EGG

0.141 (−0.057 to 0.339)

0.172

0.111 (−0.106 to 0.328)

0.315

−0.149 (− 0.989 to 0.691)

0.728

0.011 (−0.02 to 0.042)

0.487

Puberty height single height measurement(SD), cm

 10F & 12 M

EGG

0.835 (0.631 to 1.038)

8.36 × 10−10

0.77 (0.556 to 0.985)

2.2 × 10−12

0.963 (0.086 to 1.841)

0.031

−0.005 (−0.037to 0.027)

0.768

 10F

EGG

0.747 (0.452 to 1.041)

1.37 × 10−05

0.8 (0.506 to 1.094)

7.7 × 10−08

0.509 (− 0.758 to 1.775)

0.431

0.009 (−0.038 to 0.056)

0.705

 12 M

EGG

0.828 (0.557 to 1.1)

5.63 × 10−07

0.834 (0.549 to 1.12)

1.0 × 10− 08

0.953 (− 0.218 to 2.125)

0.111

−0.005 (− 0.048 to 0.038)

0.83

  1. The threshold of significance was at the Bonferroni-adjusted level P < 0.0026 (0.05/40 = 0.00125)
  2. 10F Height SDS for females at age 10, 12 M Height SDS for males at age 12, 10F&12 M Height SDS for females at age 10 and males at age 12 combined