From: Maternal central obesity and birth size: a Mendelian randomization analysis
Outcomes | Consortium | Maternal HIPadjBMI (value of 1 SD with units, GIANT) | |||||||
---|---|---|---|---|---|---|---|---|---|
Main analysis | Sensitivity analysis | ||||||||
IVW | Weighted-median | MR-Egger | |||||||
β (95% CI) | P-value | β (95% CI) | P-value | β (95% CI) | P-value | Intercept (95% CI) | P-value | ||
Birth length(SD), cm | |||||||||
 Birth length | EGG | 0.392(0.258 to 0.526) | 1.12 × 10−06 | 0.433 (0.291 to 0.574) | 2.2 × 10−09 | 0.798 (0.247 to 1.349) | 0.005 | −0.015 (− 0.036 to 0.005) | 0.136 |
Birth weight(SD), kg | |||||||||
 Birth weight | EGG | 0.168 (0.093 to 0.242) | 7.1 × 10−05 | 0.175 (0.108 to 0.241) | 2.5 × 10−07 | 0.153 (− 0.157 to 0.464) | 0.332 | 0.001 (−0.011 to 0.012) | 0.972 |
Head circumference (HC)(SD), cm | |||||||||
 HC | EGG | 0.141 (−0.057 to 0.339) | 0.172 | 0.111 (−0.106 to 0.328) | 0.315 | −0.149 (− 0.989 to 0.691) | 0.728 | 0.011 (−0.02 to 0.042) | 0.487 |
Puberty height single height measurement(SD), cm | |||||||||
 10F & 12 M | EGG | 0.835 (0.631 to 1.038) | 8.36 × 10−10 | 0.77 (0.556 to 0.985) | 2.2 × 10−12 | 0.963 (0.086 to 1.841) | 0.031 | −0.005 (−0.037to 0.027) | 0.768 |
 10F | EGG | 0.747 (0.452 to 1.041) | 1.37 × 10−05 | 0.8 (0.506 to 1.094) | 7.7 × 10−08 | 0.509 (− 0.758 to 1.775) | 0.431 | 0.009 (−0.038 to 0.056) | 0.705 |
 12 M | EGG | 0.828 (0.557 to 1.1) | 5.63 × 10−07 | 0.834 (0.549 to 1.12) | 1.0 × 10− 08 | 0.953 (− 0.218 to 2.125) | 0.111 | −0.005 (− 0.048 to 0.038) | 0.83 |