Skip to main content

Table 2 Mendelian randomization analyses of maternal waist circumference and birth size and puberty height

From: Maternal central obesity and birth size: a Mendelian randomization analysis

Outcomes

Consortium

Maternal WCajdBMI (value of 1 SD with units, GIANT)

Main analysis

Sensitivity analysis

IVW

Weighted-median

MR-Egger

β (95% CI)

P-value

β (95% CI)

P-value

β (95% CI)

P-value

Intercept (95% CI)

P-value

Birth length(SD), cm

 Birth length

EGG

0.279 (0.095 to 0.464)

0.007

0.251 (0.057 to 0.446)

0.011

0.484 (−0.361 to 1.328)

0.262

−0.007 (− 0.036 to 0.022)

0.627

Birth weight(SD), kg

 Birth weight

EGG

0.114 (−0.028 to 0.255)

0.129

0.001 (−0.074 to 0.077)

0.977

0.1 (−0.524 to 0.723)

0.753

0.001 (−0.022 to 0.023)

0.964

Head circumference (HC)(SD),cm

 HC

EGG

−0.02 (− 0.199 to 0.159)

0.821

0.039 (−0.21 to 0.288)

0.76

−0.304 (−1.092 to 0.484)

0.45

0.01 (−0.016 to − 0.036)

0.452

Puberty height single height measurement(SD), cm

 10F & 12 M

EGG

0.345 (0.059 to 0.632)

0.027

0.358 (0.088 to 0.627)

0.009

0.359 (− 1.138 to 1.856)

0.638

0 (−0.051 to 0.05)

0.985

 10F

EGG

0.379 (0.103 to 0.655)

0.013

0.305 (−0.018 to 0.628)

0.064

−0.132 (−1.371 to 1.108)

0.835

0.018(−0.025 to 0.061)

0.407

 12 M

EGG

0.303 (−0.022 to 0.627)

0.081

0.194(− 0.171 to 0.558)

0.297

0.948 (−0.727 to 2.623)

0.267

−0.022 (− 0.078 to 0.034)

0.441

  1. The threshold of significance was at the Bonferroni-adjusted level P < 0.0026 (0.05/25 = 0.002)
  2. 10F Height SDS for females at age 10, 12 M Height SDS for males at age 12, 10F&12 M Height SDS for females at age 10 and males at age 12 combined