From: Maternal central obesity and birth size: a Mendelian randomization analysis
Outcomes | Consortium | Maternal WCajdBMI (value of 1 SD with units, GIANT) | |||||||
---|---|---|---|---|---|---|---|---|---|
Main analysis | Sensitivity analysis | ||||||||
IVW | Weighted-median | MR-Egger | |||||||
β (95% CI) | P-value | β (95% CI) | P-value | β (95% CI) | P-value | Intercept (95% CI) | P-value | ||
Birth length(SD), cm | |||||||||
 Birth length | EGG | 0.279 (0.095 to 0.464) | 0.007 | 0.251 (0.057 to 0.446) | 0.011 | 0.484 (−0.361 to 1.328) | 0.262 | −0.007 (− 0.036 to 0.022) | 0.627 |
Birth weight(SD), kg | |||||||||
 Birth weight | EGG | 0.114 (−0.028 to 0.255) | 0.129 | 0.001 (−0.074 to 0.077) | 0.977 | 0.1 (−0.524 to 0.723) | 0.753 | 0.001 (−0.022 to 0.023) | 0.964 |
Head circumference (HC)(SD),cm | |||||||||
 HC | EGG | −0.02 (− 0.199 to 0.159) | 0.821 | 0.039 (−0.21 to 0.288) | 0.76 | −0.304 (−1.092 to 0.484) | 0.45 | 0.01 (−0.016 to − 0.036) | 0.452 |
Puberty height single height measurement(SD), cm | |||||||||
 10F & 12 M | EGG | 0.345 (0.059 to 0.632) | 0.027 | 0.358 (0.088 to 0.627) | 0.009 | 0.359 (− 1.138 to 1.856) | 0.638 | 0 (−0.051 to 0.05) | 0.985 |
 10F | EGG | 0.379 (0.103 to 0.655) | 0.013 | 0.305 (−0.018 to 0.628) | 0.064 | −0.132 (−1.371 to 1.108) | 0.835 | 0.018(−0.025 to 0.061) | 0.407 |
 12 M | EGG | 0.303 (−0.022 to 0.627) | 0.081 | 0.194(− 0.171 to 0.558) | 0.297 | 0.948 (−0.727 to 2.623) | 0.267 | −0.022 (− 0.078 to 0.034) | 0.441 |