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Table 1 Mendelian randomization analyses of maternal waist-to-hip ratio and birth size and puberty height

From: Maternal central obesity and birth size: a Mendelian randomization analysis

Outcomes

Consortium

Maternal WHRajdBMI (value of 1 SD with units, GIANT)

Main analysis

Sensitivity analysis

IVW

Weighted-median

MR-Egger

β (95% CI)

P-value

β (95% CI)

P-value

β (95% CI)

P-value

Intercept (95%CI)

P-value

Birth length(SD), cm

 Birth length

EGG

−0.01 (− 0.154 to 0.135)

0.896

− 0.03 (− 0.169 to 0.109)

0.675

−0.029 (− 0.583 to 0.524)

0.918

0.001 (− 0.02 to 0.021)

0.943

Birth weight(SD), kg

 Birth weight

EGG

−0.021 (− 0.095 to 0.053)

0.579

−0.015 (− 0.073 to 0.043)

0.622

0.142 (−0.136 to 0.419)

0.317

−0.006 (− 0.017 to 0.004)

0.232

Head circumference (HC)(SD), cm

 HC

EGG

−0.01 (− 0.154 to 0.135)

0.896

−0.03 (− 0.169 to 0.109)

0.675

−0.029 (− 0.583 to 0.524)

0.918

0.001 (− 0.02 to 0.021)

0.943

Puberty height single height measurement(SD), cm

 10F & 12 M

EGG

−0.10 (− 0.26 to 0.05)

0.207

−0.05 (− 0.24 to 0.14)

0.604

−0.23 (− 0.86 to 0.39)

0.466

0.005 (− 0.018 to 0.028)

0.678

 10F

EGG

−0.064 (−0.267 to 0.137)

0.537

−0.09 (− 0.352 to 0.172)

0.499

−0.078 (− 0.843 to 0.687)

0.841

0.001 (−0.028 to 0.029)

0.97

 12 M

EGG

−0.062 (−0.252 to 0.128)

0.529

−0.058 (− 0.317 to 0.201)

0.662

0.128 (−0.62 to 0.876)

0.738

−0.007 (− 0.035 to 0.02)

0.607

  1. The threshold of significance was at the Bonferroni-adjusted level P < 0.0026 (0.05/35 = 0.00142)
  2. 10F Height SDS for females at age 10, 12 M Height SDS for males at age 12, 10F&12 M Height SDS for females at age 10 and males at age 12 combined