From: Maternal central obesity and birth size: a Mendelian randomization analysis
Outcomes | Consortium | Maternal WHRajdBMI (value of 1 SD with units, GIANT) | |||||||
---|---|---|---|---|---|---|---|---|---|
Main analysis | Sensitivity analysis | ||||||||
IVW | Weighted-median | MR-Egger | |||||||
β (95% CI) | P-value | β (95% CI) | P-value | β (95% CI) | P-value | Intercept (95%CI) | P-value | ||
Birth length(SD), cm | |||||||||
 Birth length | EGG | −0.01 (− 0.154 to 0.135) | 0.896 | − 0.03 (− 0.169 to 0.109) | 0.675 | −0.029 (− 0.583 to 0.524) | 0.918 | 0.001 (− 0.02 to 0.021) | 0.943 |
Birth weight(SD), kg | |||||||||
 Birth weight | EGG | −0.021 (− 0.095 to 0.053) | 0.579 | −0.015 (− 0.073 to 0.043) | 0.622 | 0.142 (−0.136 to 0.419) | 0.317 | −0.006 (− 0.017 to 0.004) | 0.232 |
Head circumference (HC)(SD), cm | |||||||||
 HC | EGG | −0.01 (− 0.154 to 0.135) | 0.896 | −0.03 (− 0.169 to 0.109) | 0.675 | −0.029 (− 0.583 to 0.524) | 0.918 | 0.001 (− 0.02 to 0.021) | 0.943 |
Puberty height single height measurement(SD), cm | |||||||||
 10F & 12 M | EGG | −0.10 (− 0.26 to 0.05) | 0.207 | −0.05 (− 0.24 to 0.14) | 0.604 | −0.23 (− 0.86 to 0.39) | 0.466 | 0.005 (− 0.018 to 0.028) | 0.678 |
 10F | EGG | −0.064 (−0.267 to 0.137) | 0.537 | −0.09 (− 0.352 to 0.172) | 0.499 | −0.078 (− 0.843 to 0.687) | 0.841 | 0.001 (−0.028 to 0.029) | 0.97 |
 12 M | EGG | −0.062 (−0.252 to 0.128) | 0.529 | −0.058 (− 0.317 to 0.201) | 0.662 | 0.128 (−0.62 to 0.876) | 0.738 | −0.007 (− 0.035 to 0.02) | 0.607 |