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Table 1 Association analysis of the three VDR SNPs and cases (stage I)

From: Vitamin D receptor polymorphism rs2228570 is significantly associated with risk of dyslipidemia and serum LDL levels in Chinese Han population

SNP

Group

Genotype OR (95% CI)a

Allele

  

WT

Ht+ MT

Additive

Dominant

Recessive

Major/Minor

OR (95% CI)

P -value

rs11574129

 

TT

TC + CC

   

T/C

  
 

Control

1265

560 + 55

1.069 (0.923–1.238)

1.055 (0.89–1.25)

1.2 6 (0.809–1.964)

3090/670

1.07 (0.92–1.24)

0.46c

 

case

578

265 + 32

P = 0.376

P = 0.536

P = 0.306

1421/329

 

0.38b

rs2228570

 

CC

TC + TT

   

C/T

  
 

Control

539

939 + 401

1.255 (1.118–1.409)

1.384 (1.136–1.6)

1.356 (1.1–1.671)

2017/1741

1.25 (1.12-1.41)

0.832c

 

case

308

422 + 146

P < 0.001

P =0.001

P = 0.004

1038/714

 

0.001b

rs739837

 

CC

TC + TT

   

C/T

  
 

Control

991

749 + 139

1.094 (0.965–1.241)

1.108 (0.944–1.301)

1.157 (0.862–1.553)

2731/1027

1.09 (0.96–1.24)

0.877c

 

case

439

362 + 74

P =0.161

P = 0.209

P = 0.33

1240/510

 

0.17b

  1. a Adjusted for sex and age
  2. b P-value of χ2 test for comparison of allele between case and control group
  3. c P-value of Fisher’s exact χ2 test for HWE
  4. WT wild type, Ht heterozygote, MT mutant type
  5. OR Odds ratio
  6. CI Confidence interval