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Table 2 Associations of GCKR and G6PC2 SNPs with risk of T2DM

From: Gene-gene interactions lead to higher risk for development of type 2 diabetes in a Chinese Han population: a prospective nested case-control study

Genotype

Crude odds ratio (95% CI)

P value

Adjusted odds ratio (95% CI)

Pa value

rs780094

 TT

1.00

 

1.00

 

 CT

0.889 (0.643–1.229)

0.476

1.296 (0.811–2.072)

0.278

 CC

1.058 (0.726–1.541)

0.768

1.779 (1.028–3.078)

0.040

 each C-allele increase

1.028 (0.852–1.240)

0.774

1.334 (1.014–1.755)

0.039

Dominant model

 CC + CT vs. TT

0.941 (0.694–1.277)

0.697

1.434 (0.918–2.240)

0.113

Recessive model

 CC vs. CT + TT

1.145 (0.842–1.557)

0.389

1.490 (0.955–2.324)

0.079

rs2293572

 CC

1.00

–

1.00

–

 GC + GG

1.177 (0.872–1.589)

0.286

0.948 (0.625–1.438)

0.803

rs1260326

 CC

1.00

 

1.00

 

 CT

0.925 (0.668–1.281)

0.639

1.334 (0.831–2.141)

0.233

 TT

0.972 (0.669–1.412)

0.972

1.666 (0.963–2.880)

0.068

 each T-allele increase

0.986 (0.819–1.189)

0.886

1.290 (0.981–1.696)

0.068

Dominant model

 TT + CT vs. CC

0.940 (0.692–1.279)

0.695

1.433 (0.914–2.247)

0.117

Recessive model

 TT vs. CT + CC

1.024 (0.757–1.386)

0.877

1.364 (0.881–2.111)

0.164

rs492594

 GG

1.00

–

1.00

–

 GC

0.724 (0.523–1.003)

0.052

0.567 (0.362–0.888)

0.013

 CC

0.832 (0.569–1.219)

0.345

0.678 (0.401–1.147)

0.147

 each C-allele increase

0.907 (0.750–1.096)

0.311

0.813 (0.626–1.055)

0.119

Dominant model

 CC + GC vs. GG

0.758 (0.558–1.029)

0.076

0.601 (0.394–0.916)

0.018

Recessive model

 CC vs. GG + GC

1.026 (0.748–1.408)

0.872

0.977 (0.633–1.509)

0.916

rs16856187

 AA

1.00

–

1.00

–

 CA

0.991 (0.762–1.289)

0.948

1.037 (0.729–1.476)

0.839

 CC

0.929 (0.547–1.580)

0.787

1.552 (0.656–3.670)

0.317

 each C-allele increase

0.978 (0.794–1.204)

0.832

1.113 (0.829–1.495)

0.475

Dominant model

 CA + CC vs. AA

0.983 (0.763–1.268)

0.897

1.077 (0.764–1.519)

0.671

Recessive model

 CC vs. AA+CA

0.933 (0.558–1.562)

0.793

1.526 (0.655–3.556)

0.327

rs13387347

 TT

1.00

–

1.00

–

 CT

0.892 (0.662–1.203)

0.764

0.802 (0.533–1.206)

0.289

 CC

1.080 (0.732–1.592)

0.699

1.469 (0.850–2.539)

0.169

 each C-allele increase

1.014 (0.840–1.225)

0.885

1.117 (0.862–1.447)

0.401

Dominant model

 CT + CC vs. TT

0.941 (0.711–1.245)

0.668

0.947 (0.649–1.381)

0.777

Recessive model

 CC vs. TT + CT

1.153 (0.813–1.633)

0.425

1.651 (0.998–2.731)

0.051

  1. Adjusted for BMI, BMI-change, smoking, drinking, family history of diabetes
  2. Pa value is adjusted result
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Lipids in Health and Disease

ISSN: 1476-511X