Table 8 Effect of δ-tocotrienol on down-regulation of fold change expression in “upstream regulators” section (64) of IPA analysis in hepatitis C patients
# | Upstream Regulator | Molecule Type | Predicted Activation State | Activation z-score | p-value of overlap | Mechanistic Network |
|---|---|---|---|---|---|---|
Down-regulated | ||||||
1 | interferon beta-1a | biologic drug | 9.17E-14 | |||
2 | IL2 | cytokine | Inhibited | -4.562 | 2.23E-09 | 297 (17) |
3 | IL15 | cytokine | Inhibited | -2.247 | 1.37E-08 | 299 (19) |
4 | FAS | transmembrane receptor | -1.461 | 3.94E-08 | 263 (17) | |
5 | TNF | cytokine | Inhibited | -5.914 | 0.000000294 | 378 (19) |
6 | IL21 | cytokine | Inhibited | -2.747 | 0.00000339 | 264 (15) |
7 | GATA1 | transcription regulator | -0.822 | 0.00000497 | 243 (11) | |
8 | IRF1 | transcription regulator | Inhibited | -3.223 | 0.000011 | 245 (13) |
9 | EGF | growth factor | Inhibited | -5.15 | 0.0000204 | 303 (15) |
10 | TGFB1 | growth factor | Inhibited | -3.491 | 0.00004 | 350 (17) |
11 | IL6 | cytokine | Inhibited | -3.043 | 0.0000566 | 284 (15) |
12 | IL5 | cytokine | Inhibited | -4.866 | 0.0000654 | 243 (13) |
13 | Interferon alpha | group | Inhibited | -4.069 | 0.000154 | 150 (9) |
14 | STAT4 | transcription regulator | Inhibited | -4.536 | 0.000489 | 111 (6) |
15 | IL7 | cytokine | Inhibited | -2.665 | 0.00064 | 243 (18) |
16 | IL13 | cytokine | -1.516 | 0.000806 | 295 (16) | |
17 | STAT1 | transcription regulator | Inhibited | -4.582 | 0.000877 | 241 (14) |
18 | IL1B | cytokine | Inhibited | -4.367 | 0.000982 | 330 (17) |
19 | STAT2 | transcription regulator | Inhibited | -2.219 | 0.00105 | 173 (9) |
20 | PARP9 | enzyme | Inhibited | -2.200 | 0.00123 | 142 (6) |
21 | FOXC1 | transcription regulator | -1.961 | 0.002 | ||
22 | IL2RG | transmembrane receptor | -0.113 | 0.00233 | ||
23 | IL12 (complex) | complex | Inhibited | -2.378 | 0.00251 | 246 (17) |
24 | TGFA | growth factor | Inhibited | -2.888 | 0.00327 | 283 (17) |
25 | CD14 | transmembrane receptor | -1.768 | 0.00332 | 298 (16) | |
26 | TNFSF10 | cytokine | -1.376 | 0.00477 | 297 (17) | |
27 | mir-223 | microrna | Inhibited | -2.060 | 0.00527 | 167 (7) |
28 | IL27 | cytokine | Inhibited | -2.937 | 0.00527 | 317 (16) |
29 | beta-estradiol | chemical - endogenous mammalian | Inhibited | -4.574 | 0.00546 | 358 (17) |
30 | IL10 | cytokine | -0.803 | 0.00582 | 247 (17) | |
31 | ADORA2A | g-protein coupled receptor | Inhibited | -2.365 | 0.00599 | 175 (9) |
32 | IFNL1 | cytokine | Inhibited | -2.925 | 0.00622 | 224 (11) |
33 | IL18 | cytokine | Inhibited | -2.26 | 0.00701 | 326 (19) |
34 | NOX1 | ion channel | -1.951 | 0.00741 | 263 (14) | |
35 | SOX4 | transcription regulator | Inhibited | -3.033 | 0.00834 | |
36 | prostaglandin J2 | chemical - endogenous non-mammalian | -1.432 | 0.0115 | ||
37 | E2F1 | transcription regulator | Inhibited | -2.081 | 0.0142 | |
38 | CREB1 | transcription regulator | Inhibited | -3.766 | 0.0143 | |
39 | IGF1 | growth factor | Inhibited | -2.385 | 0.0158 | |
40 | IL12 (family) | group | -0.500 | 0.016 | ||
41 | IRF5 | transcription regulator | Inhibited | -2.155 | 0.0162 | |
42 | FOXO4 | transcription regulator | -1.98 | 0.0179 | ||
43 | PGF | growth factor | -1.959 | 0.0237 | ||
44 | BTG2 | transcription regulator | 1.165 | 0.0239 | ||
45 | mir-15 | microrna | -0.927 | 0.0279 | ||
46 | STAT5A | transcription regulator | -0.896 | 0.0294 | ||
47 | NFE2L2 | transcription regulator | Inhibited | -3.644 | 0.0295 | |
48 | MIF | cytokine | Inhibited | -2.642 | 0.0304 | |
49 | FGF10 | growth factor | Inhibited | -2.200 | 0.0305 | |
50 | miR-26a-5p (and other miRNAs w/seed UCAAGUA) | mature microrna | 1.916 | 0.0309 | ||
51 | NOX4 | enzyme | -1.941 | 0.0309 | ||
52 | NFKBIB | transcription regulator | -1.400 | 0.0331 | ||
53 | IFNA1/IFNA13 | cytokine | -1.77 | 0.0331 | ||
54 | FLT3LG | cytokine | Inhibited | -2.411 | 0.0331 | |
55 | IL17F | cytokine | -1.917 | 0.0349 | ||
56 | IL32 | cytokine | -1.15 | 0.0416 | ||
57 | CCL5 | cytokine | Inhibited | -2.621 | 0.042 | |
58 | IL17A | cytokine | Inhibited | -3.075 | 0.0422 | |
59 | MIR124 | group | 1.941 | 0.0435 | ||
60 | miR-218-5p (and other miRNAs w/seed UGUGCUU) | mature microrna | 0.0443 | |||
61 | CXCR4 | g-protein coupled receptor | -0.842 | 0.0447 | ||
62 | CD38 | enzyme | Inhibited | -3.429 | 0.0482 | |
63 | IL24 | cytokine | -0.277 | 0.0498 | ||
64 | TCF3 | transcription regulator | Inhibited | -2.530 | 0.231 | |