Effect of lipid and cellulose based matrix former on the release of highly soluble drug from extruded/spheronized, sintered and compacted pellets

Table 3 Physical and chemical evaluation of matrix and sintered pellet formulations

Formulations	Bulk Density g/ml	Tapped Density g/ml	Angle of Repose θ	Carr’s Index %	Hausner’s Ratio	Assay %
F00	0.625	0.704	23.08	11.222	1.126	101.481
F0	0.557	0.597	21.23	6.700	1.072	101.373
F1	0.675	0.709	52.19	4.795	1.050	101.872
F2	0.687	0.712	53.23	3.511	1.036	100.998
F3	0.654	0.698	54.18	6.304	1.067	101.623
F4	0.769	0.806	55.54	4.591	1.048	100.749
F5	0.826	0.931	27.56	11.278	1.127	99.987
F6	0.8	0.967	25.27	17.270	1.209	98.765
F7	0.654	0.765	26.15	14.510	1.170	101.675
F8	0.554	0.578	26.56	4.152	1.043	100.765
F9	0.567	0.6	29.54	5.500	1.058	100.653
F10	0.674	0.713	27.56	5.470	1.058	99.765
F11	0.598	0.67	27.89	10.746	1.120	99.876
F12	0.479	0.501	28.98	4.391	1.046	97.676
F13	0.675	0.698	30.23	3.295	1.034	100.109
F14	0.775	0.891	30.78	13.019	1.150	100.657
F15	0.765	0.865	31.78	11.561	1.131	101.762
F16	0.567	0.613	29.76	7.504	1.081	101.765
F17	0.767	0.897	26.67	14.493	1.169	100.765
F18	0.765	0.887	28.56	13.754	1.159	100.675
F19	0.897	0.953	32.33	5.876	1.062	101.876
F20	0.785	0.866	32.87	9.353	1.103	101.767
F21	0.764	0.824	33.32	7.282	1.079	98.765
F22	0.745	0.867	28.56	14.072	1.164	99.762
F23	0.699	0.765	28.76	8.627	1.094	100.765
F24	0.776	0.845	26.87	8.166	1.089	99.765
F25	0.798	0.878	30.76	9.112	1.100	98.766
F26	0.687	0.786	27.67	12.595	1.144	99.765
F27	0.657	0.759	27.56	13.439	1.155	101.673
F28	0.765	0.823	28.65	7.047	1.076	100.783
F29	0.734	0.845	25.22	13.136	1.151	100.786
F30	0.765	0.876	25.87	12.671	1.145	101.783
F31	0.734	0.823	23.78	10.814	1.121	100.672
F32	0.71	0.83	25.78	14.458	1.169	100.37
F33	0.76	0.9	27.4	15.556	1.184	100
F34	0.83	0.95	28.7	12.632	1.145	99.87
F35	0.9	1.11	27.8	18.919	1.233	100.12

ISSN: 1476-511X