Table 3 The association between inositol intake and lipid profiles based on subgroup analysis
Variables | Number of SMD included | Subgroups | Pooled OR (random effect) | 95% CI | I2 (%) | Overall I2 (%) | |
|---|---|---|---|---|---|---|---|
Triglycerides | Type of disease | 5 | PCOS | −0.74 | −1.66, 0.18 | 91.7 | 93.2 |
7 | Non-PCOS | −1.58 | −2.32, −0.85 | 92.1 | |||
Dosage of inositol (mg/day) | 6 | ≥2000 | −0.83 | −1.49, − 0.18 | 83.4 | ||
6 | <2000 | −1.69 | −2.69, −0.68 | 96.2 | |||
Duration of study (week) | 5 | ≥14 | −1.64 | −2.94, −0.34 | 93.4 | ||
7 | <14 | −0.99 | −1.67, − 0.32 | 93.1 | |||
Type of intervention | 4 | DCI | −0.32 | −0.66, 0.01 | 0.0 | ||
6 | MI | −1.15 | −1.91, −0.39 | 94.0 | |||
2 | MI + DCI | −3.37 | −6.00, −0.75 | 94.2 | |||
Total cholesterol | Type of disease | 5 | PCOS | −0.86 | −1.72, − 0.02 | 90.3 | 93.6 |
6 | Non-PCOS | −1.49 | −2.51, −0.46 | 95.5 | |||
Dosage of inositol (mg/day) | 5 | ≥2000 | −0.82 | −1.91, 0.28 | 92.2 | ||
6 | <2000 | −1.51 | −2.38, −0.63 | 95.2 | |||
Duration of study (week) | 5 | ≥14 | −1.77 | −3.31, −0.22 | 95.0 | ||
6 | <14 | −0.74 | −1.33, − 0.15 | 90.5 | |||
Type of intervention | 4 | DCI | −0.22 | −0.62, 0.18 | 26.2 | ||
5 | MI | −0.91 | −1.59, − 0.24 | 91.9 | |||
2 | MI + DCI | −3.76 | −5.68, −1.85 | 88.2 | |||
LDL-cholesterol | Type of disease | 3 | PCOS | −0.60 | −1.51, 0.31 | 86.1 | 92.2 |
2 | Non-PCOS | −1.84 | −3.41, 0.26 | 93.1 | |||
Dosage of inositol (mg/day) | 3 | ≥2000 | −0.86 | −2.27, 0.54 | 93.2 | ||
2 | <2000 | −2.00 | −3.98, −0.03 | 94.8 | |||
Duration of study (week) | 4 | ≥14 | −1.39 | −2.78, −0.01 | 94.0 | ||
1 | <14 | −1.03 | − 1.37, −0.70 | 0.0 | |||
Type of intervention | 2 | DCI | −0.15 | − 0.61, 0.30 | 0.0 | ||
1 | MI | −1.03 | −1.37, −0.70 | – | |||
2 | MI + DCI | −2.59 | −3.39, −1.81 | 56.7 | |||
HDL-cholesterol | Type of disease | 3 | PCOS | 0.38 | 0.12, 0.64 | 2.4 | 89.4 |
7 | Non-PCOS | 0.14 | −0.56, 0.84 | 92.7 | |||
Dosage of inositol (mg/day) | 5 | ≥2000 | 0.01 | −0.59, 0.62 | 81.1 | ||
5 | <2000 | 0.37 | −0.31, 1.04 | 92.2 | |||
Duration of study (week) | 4 | ≥14 | −0.61 | −1.35, 0.14 | 83.5 | ||
6 | <14 | 0.68 | 0.42, 0.95 | 55.1 | |||
Type of intervention | 3 | DCI | 0.19 | −0.17, 0.55 | 0.0 | ||
5 | MI | 0.72 | 0.42, 1.02 | 62.0 | |||
2 | MI + DCI | −1.22 | −1.73, −0.71 | 36.2 | |||