Fig. 4
From: Eicosapentaenoic acid ethyl ester improves endothelial dysfunction in type 2 diabetic mice
Effects of EPA-E, the metabolites and the solvent, methanol on the aortic rings extracted from C57BL/6 J mice in vitro. Original tracings showing that these reagents stimulated relaxation of the aorta after precontraction with prostaglandin F2α. EPA-E and methanol (a solvent of all fatty acids) did not relax the C57BL/6 J aortic rings (a, b). The EPA-E metabolites EPA, DPA, and DHA induced vasodilation in the aortic rings (c, e, f). In the presence of L-NNA, the relaxation induced by EPA was decreased in the aortic rings (d). Data are expressed as mean ± SEM; n = 8; ***P < 0.001 vs. Vehicle