Fig. 2

Endotoxin alters the quantity and distribution of apo B-containing lipoprotein subclasses. Plasma (a) apoB and apoB-containing lipoprotein subclasses: (b) LpB, (c) LpB:C, (d) LpB:C + LpB:E and (e) LpA-II:B:C:D:E concentrations measured at baseline and for 8 h after an intravenous dose of endotoxin (closed circles, n = 11) or saline (open circles, n = 9). Data were analyzed by 2-way repeated measures ANOVA (time x LPS treatment) with Dunnett’s posthoc analysis for time points compared to baseline in saline (+; p < 0.05) or LPS (#; p < 0.05) groups. A Sidak’s multiple comparison test was used to compare treatment groups at each time point (*; p < 0.05). (f) The percent change from baseline in TGRLP subclass distribution at 6 h and 8 h after an intravenous dose of LPS or saline. To compare group changes within each subclass, data were analyzed by 2-way ANOVA (TGLRP composition vs. time) with Tukey post hoc analysis. * p < 0.05 compared to saline within subclass. Significant difference (P < 0.05) between subclasses letters at 6 or 8 h are marked with different letter