Categories | n | Sample size | G VS T | GG + GT VS TT | GG VS GT + TT | GT VS TT | GG VS TT | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case/Control | OR (95% CI) | P | I2(%)/Ph | OR (95% CI) | P | I2(%)/Ph | OR (95% CI) | P | I2(%)/Ph | OR (95% CI) | P | I2(%)/Ph | OR (95% CI) | P | I2(%)/Ph | ||
Overall | 40 | 10,746/14,802 | 1.216 (1.102, 1.343) | < 0.001 | 72.4/0.000 | 1.229 (1.103, 1.369) | < 0.001 | 65.6/0.000 | 1.286 (1.061, 1.560) | 0.011 | 49.7/0.000 | 1.172 (1.063, 1.292) | 0.001 | 53.3/0.000 | 1.361 (1.095, 1.690) | 0.005 | 57.7/0.000 |
Population | |||||||||||||||||
 European | 12 | 4,452/7,255 | 1.067 (0.918, 1.242) | 0.398 | 60.4/0.003 | 1.105 (0.937, 1.303) | 0.238 | 58.3/0.006 | 0.779 (0.576, 1.055) | 0.106 | 0.0/0.663 | 1.123 (0.956, 1.319) | 0.157 | 53.0/0.015 | 0.792 (0.584, 1.073) | 0.132 | 0.0/0.585 |
 East Asian | 20 | 5,305/6,505 | 1.194 (1.057, 1.348) | 0.004 | 70.5/0.000 | 1.225 (1.057, 1.420) | 0.007 | 67.3/0.000 | 1.315 (1.068, 1.618) | 0.010 | 43.1/0.024 | 1.180 (1.029, 1.353) | 0.018 | 58.1/0.001 | 1.431 (1.112, 1.842) | 0.005 | 58.6/0.001 |
 West Asian |   5 | 660/719 | 1.550 (1.002, 2.396) | 0.049 | 80.8/0.000 | 1.392 (0.893, 2.170) | 0.145 | 71.3/0.007 | 2.715 (1.452, 5.079) | 0.002 | 50.2/0.091 | 1.099 (0.779, 1.549) | 0.591 | 43.2/0.134 | 2.767 (1.347, 5.683) | 0.006 | 59.2/0.044 |
 African |   3 | 329/323 | 2.200 (0.890, 5.437) | 0.088 | 75.3/0.017 | 2.148 (0.952, 4.844) | 0.066 | 65.2/0.056 | 2.010 (0.251, 16.080) | 0.511 | 50.8/0.154 | 1.919 (0.998, 3.688) | 0.051 | 45.1/0.162 | 2.295 (0.250, 21.058) | 0.463 | 55.2/0.135 |
Genotyping | |||||||||||||||||
 PCR-RFLP | 20 | 4,814/6,319 | 1.242 (1.055, 1.462) | 0.009 | 77.1/0.000 | 1.279 (1.057, 1.548) | 0.012 | 74.4/0.000 | 1.335 (1.034, 1.722) | 0.027 | 40.5/0.035 | 1.221 (1.023, 1.458) | 0.027 | 67.0/0.000 | 1.442 (1.054, 1.975) | 0.022 | 57.1/0.001 |
 TaqMan |   7 | 2,616/3,715 | 1.087 (0.895, 1.320) | 0.400 | 64.8/0.009 | 1.118 (0.920, 1.357) | 0.262 | 53.9/0.043 | 0.872 (0.513, 1.482) | 0.614 | 56.9/0.041 | 1.123 (0.951, 1.326) | 0.172 | 34.9/0.162 | 0.896 (0.506, 1.588) | 0.708 | 62.2/0.021 |
 Other | 13 | 3,316/4,768 | 1.263 (1.075, 1.485) | 0.005 | 68.7/0.000 | 1.238 (1.056, 1.452) | 0.009 | 51.4/0.016 | 1.453 (1.021, 2.066) | 0.038 | 56.7/0.006 | 1.150 (1.004, 1.317) | 0.044 | 27.6/0.166 | 1.522 (1.056, 2.193) | 0.024 | 57.7/0.005 |
Sample size | |||||||||||||||||
  < 1000 | 34 | 7,651/6,381 | 1.298 (1.164, 1.448) | < 0.001 | 66.6/0.000 | 1.317 (1.163, 1.492) | < 0.001 | 61.1/0.000 | 1.512 (1.264, 1.809) | < 0.001 | 25.5/0.096 | 1.239 (1.102, 1.393) | < 0.001 | 51.4/0.000 | 1.620 (1.324, 1.981) | < 0.001 | 35.9/0.024 |
  ≥ 1000 |   6 | 3,095/8,421 | 0.920 (0.834, 1.015) | 0.097 | 23.9/0.255 | 0.945 (0.841, 1.062) | 0.344 | 25.5/0.243 | 0.690 (0.539, 0.885) | 0.003 | 0.0/0.758 | 0.981 (0.879, 1.094) | 0.728 | 11.3/0.343 | 0.669 (0.519, 0.862) | 0.002 | 0.0/0.661 |
Quality score | |||||||||||||||||
  < 10 | 26 | 5,467/4,951 | 1.366 (1.176, 1.586) | < 0.001 | 77.0/0.000 | 1.404 (1.183, 1.667) | < 0.001 | 72.8/0.000 | 1.529 (1.202, 1.944) | 0.001 | 46.0/0.008 | 1.314 (1.121, 1.539) | 0.001 | 64.4/0.000 | 1.692 (1.274, 2.248) | < 0.001 | 58.4/0.000 |
  ≥ 10 | 14 | 5,279/9,851 | 1.036 (0.944, 1.139) | 0.455 | 37.3/0.079 | 1.038 (0.955, 1.128) | 0.376 | 0.0/0.575 | 0.978 (0.719, 1.331) | 0.887 | 49.9/0.017 | 1.043 (0.956, 1.137) | 0.343 | 0.0/0.818 | 0.985 (0.725, 1.340) | 0.925 | 47.5/0.025 |