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Table 4 LFT, KFT and LD50 results of the most active derivatives

From: Novel Phenoxazinones as potent agonist of PPAR-α: design, synthesis, molecular docking and in vivo studies

Biomarker

AST (IU/L)

ALT (IU/L)

ALP (IU/L)

Urea (IU/L)

Creatinine (IU/L)

Uric acid (IU/L)

LD50 μM/kg

9f

41 ± 2.00

18.4 ± 0.80

0.8 ± 0.016

17.7 ± 0.008

1.6 ± 0.33

6.6 ± 0.02

8.0

9 k

42 ± 1.83

18.9 ± 0.42

0.7 ± 0.020

18.1 ± 0.002

1.4 ± 0.11

6.6 ± 0.03

7.6

control

40 ± 1.65

20.0 ± 0.75

0.8 ± 0.014

19.1 ± 0.008

1.5 ± 0.05

6.4 ± 0.005

8.8 [32]

  1. All data were expressed as mean ± SE (standard error). AST means aspartate aminotransferase, ALT means alanine transaminase and ALP means alkaline phosphatase