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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression

Fig. 5

AMPK-SREBP-1c pathway may be associated with the function of metformin in reducing SCD1 expression. a-c The expression of SREBP-1c is decreased by metformin in HepG2 cells exposed to high glucose and high insulin. The data are presented as the means ± SEM, n = 3–4. *p < 0.05 and **p < 0.01, versus NC; #p < 0.05 and ##p < 0.01, versus HGHIn. d and e The phosphorylation of AMPK is increased by metformin in HepG2 cells exposed to high glucose and high insulin. The data are presented as the means ± SEM, n = 3. *p < 0.05, versus NC; #p < 0.05, versus HGHIn. NC normal control, HGHIn high glucose high insulin; Met metformin

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Lipids in Health and Disease

ISSN: 1476-511X