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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression

Fig. 2

Metformin decreases the expression of lipid de novo synthesis-related genes in HepG2 cells exposed to high glucose and high insulin. a and b Metformin decreases the protein expression of SCD1 in HepG2 cells exposed to high glucose and high insulin. The data are presented as the means ± SEM, n = 3. **p < 0.01, versus NC; #p < 0.05, versus HGHIn. c Metformin decreases the mRNA expression of FAS and SCD1 in HepG2 cells exposed to high glucose and high insulin. The data are presented as the means ± SEM, n = 4. *p < 0.05 and **p < 0.01, versus NC; ##p < 0.01, versus HGHIn. NC normal control, HGHIn high glucose high insulin; Met metformin

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Lipids in Health and Disease

ISSN: 1476-511X