Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations

Qiu, Ling; Yin, Rui-Xing; Khounphinith, Eksavang; Zhang, Fen-Han; Yang, De-Zhai; Pan, Shang-Ling

doi:10.1186/s12944-018-0759-8

Lipids in Health and Disease

Table 6 Relationship between serum lipid parameters and relative factors in the males and females of the both ethnic groups

From: Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations

Lipid	Risk factor	B	Std. error	Beta	t	P
Maonan/ male
TG	Alcohol consumption	0.010	0.004	0.188	2.605	0.010
HDL-C	Alcohol consumption	0.003	0.001	0.323	4.928	0.000
	Waist circumference	−0.018	0.005	−0.480	−3.884	0.000
	Genotype	−0.070	0.027	−0.155	−2.588	0.010
LDL-C	Alcohol consumption	−0.004	0.001	−0.274	−3.851	0.000
ApoA1	Alcohol consumption	0.002	0.001	0.175	2.420	0.016
ApoA1	Waist circumference	−0.014	0.005	−0.344	−2.503	0.013
ApoB	Weight	0.008	0.003	0.432	2.449	0.015
ApoA1/ApoB	Age	−0.009	0.004	−0.174	−2.256	0.025
	Alcohol consumption	0.003	0.001	0.212	3.080	0.002
	Waist circumference	−0.022	0.009	−0.310	−2.391	0.018
Maonan/ female
TC	Age	0.011	0.005	0.141	2.335	0.020
TC	Waist circumference	0.029	0.010	0.209	2.947	0.003
TG	Waist circumference	0.026	0.006	0.308	4.530	0.000
LDL-C	Age	0.009	0.003	0.157	2.688	0.008
LDL-C	Waist circumference	0.029	0.007	0.297	4.336	0.000
ApoB	Age	0.002	0.001	0.164	2.910	0.004
ApoB	Waist circumference	0.010	0.002	0.406	6.135	0.000
ApoA1 /ApoB	Waist circumference	−0.018	0.004	−0.308	−4.507	0.000
ApoA1 /ApoB	Pulse pressure	−0.004	0.002	−0.131	−2.336	0.020
Han/ male
TG	Cigarette smoking	0.035	0.014	0.239	2.581	0.011
HDL-C	Alcohol consumption	0.002	0.001	0.194	2.099	0.038
HDL-C	Diastolic blood pressure	0.008	0.004	0.246	2.253	0.026
LDL-C	Cigarette smoking	−0.018	0.008	−0.234	−2.381	0.019
ApoA1	Cigarette smoking	0.006	0.002	0.245	2.696	0.008
	Alcohol consumption	0.002	0.001	0.376	4.258	0.000
	Genotype	−0.054	0.026	−0.185	−2.074	0.041
ApoA1 /ApoB	Cigarette smoking	0.012	0.004	0.271	3.012	0.003
	Alcohol consumption	0.003	0.001	0.258	2.952	0.004
	Genotype	−0.091	0.045	−0.180	−2.040	0.044
Han/ female
TC	Age	0.091	0.007	0.267	2.898	0.004
TG	Diastolic blood pressure	0.021	0.009	0.183	2.308	0.022
TG	Genotype	0.311	0.098	0.229	3.163	0.002
LDL-C	Age	0.023	0.005	0.380	4.254	0.000
	Height	0.176	0.073	1.156	2.426	0.016
	Weight	−0.270	0.109	−2.179	−2.487	0.014
	Body mass index	0.616	0.246	2.045	2.506	0.013
ApoB	Body mass index	0.112	0.055	1.698	2.025	0.044

TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B, ApoA1/ApoB the ratio of apolipoprotein A1 to apolipoprotein B, B unstandardized coefficient, Beta standardized coefficient. The correlation among serum lipid parameters and the genotypes and several environmental factors was determined by multivariable linear regression analyses with stepwise modeling

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ISSN: 1476-511X

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