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Table 4 Association of the SNPs with lipid traits individually

From: GWAS implicated risk variants in different genes contribute additively to increase the risk of coronary artery disease (CAD) in the Pakistani subjects

SNP

Genotype

LDL-C

HDL-C

TC

TG

rs10757274

AA

99.6 ± 28.2

53.4 ± 19

196.7 ± 52.3

205.4 ± 68.9

AG

97.3 ± 27

53.9 ± 17.4

195.2 ± 51.8

203.2 ± 71

GG

99.6 ± 27.1

50.8 ± 14.6

197.6 ± 54

203.4 ± 68.2

β(Se)

0.06 (1.52)

1.27 (0.96)

0.5 (2.9)

1.01 (3.9)

p-value

0.97

0.188

0.88

0.794

rs17465637

AA

96.3 ± 23

54.8 ± 18.1

190.7 ± 52.3

196.5 ± 68.8

AC

99.4 ± 26.8

53.6 ± 16.4

196.9 ± 52.0

206.6 ± 68.2

CC

98 ± 29.1

51.8 ± 17.9

197.1 ± 53

217.0 ± 76

β (se)

0.17 (1.6)

1.6 (1.0)

2.3 (3.1)

10.2 (4.1)

p-value

0.92

0.13

0.46

0.01

rs7025486

GG

98.3 ± 26.5

53.7 ± 17.0

195.4 ± 50.7

203 ± 70.7

AG

99.0 ± 28.0

52.9 ± 17.7

197.9 ± 54.1

206.7 ± 70.4

AA

96.8 ± 28.5

50.0 ± 16.0

192.5 ± 53.4

194.4 ± 61

β (Se)

0.19 (1.7)

1.5 (1.0)

0.07 (3.2)

1.3 (4.3)

p-value

0.91

0.16

0.98

0.76

rs17228212

TT

98.3 ± 25.5

53.1 ± 17.2

195.4 ± 52.8

204.5 ± 68.4

CT

99.2 ± 30.2

52.7 ± 17.8

198.3 ± 52.2

203.3 ± 71

CC

95.8 ± 33.3

53.1 ± 14.6

192.5 ± 50

195.6 ± 81

β (Se)

0.07 (2)

0.3 (1.2)

1.2 (3.7)

2.5 (5)

p-value

0.97

0.83

0.76

0.62

rs9818870

CC

97.7 ± 26.6

53.3 ± 17

196.8 ± 53.8

203.2 ± 68

CT

102.4 ± 29.6

52 ± 18.2

192.4 ± 43.7

203.3 ± 76.5

TT

102.9 ± 41.8

48.3 ± 17.7

206.6 ± 63.8

252.5 ± 74.0

β (Se)

4.1 (2.6)

1.6 (1.6)

1.9 (5)

6.7 (6.7)

p-value

0.11

0.35

0.7

0.32

rs1746048

TT

97.1 ± 28.2

53.5 ± 19.2

185.8 ± 50.3

205.1 ± 61.2

CT

100.4 ± 26.6

52.6 ± 16.9

195.1 ± 51

205.9 ± 72.9

CC

96.9 ± 27.8

53.3 ± 17.1

200.1 ± 54.1

201.3 ± 68.6

β (Se)

1.2 (1.6)

0.1 (1)

6.5 (3.1)

2.7 (4.2)

p-value

0.47

0.9

0.04

0.51

  1. β (Se) is the effect size with standard error. Values are mentioned as mean ± SD. The analyses were adjusted for age and gender