Table 2 Associaiton between lncRNA MALAT1 polymorphisms and CAD risk
Genotypes | Controls, n = 562 (%) | CAD, n = 508 (%) | Adjusted OR (95% CI) a | Adjusted P value a |
|---|---|---|---|---|
rs11227209 | ||||
CC | 438 (77.94) | 404 (79.53) | 1.00 | |
CG | 118 (21.00) | 100 (19.69) | 1.02 (0.74–1.43) | 0.88 |
CG/GG | 124 (22.06) | 104 (20.47) | 1.01 (0.73–1.39) | 0.97 |
C allele | 994 (88.43) | 908 (89.37) | 1.00 | |
G allele | 130 (11.57) | 108 (10.63) | 0.99 (0.74–1.33) | 0.95 |
rs619586 | ||||
AA | 404 (71.89) | 410 (80.71) | 1.00 | |
AG | 144 (25.62) | 94 (18.50) | 0.69 (0.50–0.95) | 0.02 |
AG/GG | 158 (28.11) | 98 (19.29) | 0.66 (0.48–0.91) | 0.01 |
A allele | 952 (84.70) | 914 (89.96) | 1.00 | |
G allele | 172 (15.30) | 102 (10.04) | 0.68 (0.51–0.90) | 0.007 |
rs664589 | ||||
CC | 410 (72.95) | 358 (70.47) | 1.00 | |
CG | 140 (24.91) | 140 (27.56) | 1.28 (0.94–1.73) | 0.12 |
CG/GG | 152 (27.05) | 150 (29.53) | 1.23 (0.92–1.65) | 0.17 |
C allele | 960 (85.41) | 856 (84.25) | 1.00 | |
G allele | 164 (14.59) | 160 (15.75) | 1.15 (0.89–1.50) | 0.29 |
rs3200401 | ||||
CC | 422 (75.09) | 362 (71.26) | 1.00 | |
CT | 126 (22.42) | 132 (25.98) | 1.36 (0.99–1.85) | 0.05 |
CT/TT | 140 (24.91) | 146 (28.74) | 1.31 (0.97–1.77) | 0.07 |
C allele | 970 (86.30) | 856 (84.25) | 1.00 | |
T allele | 154 (13.70) | 160 (15.75) | 1.23 (0.94–1.60) | 0.13 |