Table 4 Published studies evaluating the associations between maternal serum lipids and neonatal birth weight
First author, year | N | Range of GA at sampling (weeks) | State of blood sampling | GDM included | Major findings | Ref |
|---|---|---|---|---|---|---|
Wang, 2016 | 5218 | 4–13 | NF | Yes | Low TG level was a protective factor for LGA, while high LDL-C level was a risk factor for macrosomia. After adjusting for confounders, no significant associations were found between lipid levels and macrosomia or LGA. | [40] |
Vrijkotte, 2011 | 4162 | 13 (12–14)* | NF | No | The highest TG level was associated with a higher BWSDS and a higher prevalence of LGA than the middle quintile. | [16] |
Vrijkotte, 2012 | 4008 | 13 (12–14)* | NF | No | Elevated TG levels were associated with an increased risk of LGA. | [29] |
Parlakgumus, 2014 | 433 | < 14 | F | No | No lipids were correlated with fetal birth weight. | [23] |
Clausen, 2005 | 2050 | 17–19 | NF | Yes | High non-HDL-C and low HDL-C levels were associated with increased an risk of macrosomia. | [30] |
Liu, 2016 | 1546 | 24–28 | F | Yes | Neonatal birth weight was associated with TG levels. | [31] |
Sommer, 2015 | 699 | 28 | F | Yes | HDL-C was a predictor of birth weight. | [32] |
Cianni, 2004 | 83 | 27 ± 3.7# | F | No | TG levels were independently associated with neonatal birth weight. | [19] |
Kitajima, 2001 | 146 | 24–32 | F | No | TG levels were correlated positively with newborn weight at term. | [20] |
Mossayebi, 2014 | 154 | 25–32 | F | No | TG was an independent predictor of birth weight, LGA, and macrosomia. | [34] |
Retnakara, 2012 | 472 | 30 (28–32)* | F | No | None of the lipid measurements was independently associated with birth weight or the risk of LGA. | [22] |
Hou, 2014 | 2790 | 28–37 | F | No | High maternal TG levels were significantly associated with LGA newborns. | [35] |
Ye, 2015 | 1243 | 36–41 | F | No | HDL-C was independently associated with neonatal size and was an independent predictor for LGA. | [21] |
Jin, 2016 | 934 | 7–10 21–24 33–37 | F | Yes | High TG in late pregnancy was independently associated with increased risks of LGA and macrosomia. Relatively low HDL-C levels during pregnancy were associated with an increased risk of macrosomia. | [25] |
Kulkarni, 2013 | 631 | 18 ± 2,# 28 ± 2# | F + NF | Yes | TG was associated with birth weight at 28 weeks (unadjusted). TC at both 18 and 28 weeks were independently associated withbirth weight. | [12] |