Skip to main content

Table 3 Association of the DOCK7-ANGPTL3 SNPs and serum lipid levels in controls

From: DOCK7-ANGPTL3 SNPs and their haplotypes with serum lipid levels and the risk of coronary artery disease and ischemic stroke

Genotype

n

TC (mmol/L)

TG (mmol/L)

HDL-C (mmol/L)

LDL-C (mmol/L)

ApoA1 (g/L)

ApoB (g/L)

ApoA1/ApoB

Rs1748195

 CC

361

4.92 ± 1.11

1.37 (0.90)

1.91 ± 0.47

2.70 ± 0.77

1.42 ± 0.28

0.89 ± 0.20

1.66 ± 0.53

 CG

227

4.83 ± 1.00

1.18 (0.70)

1.88 ± 0.49

2.74 ± 0.80

1.40 ± 0.27

0.91 ± 0.22

1.62 ± 0.51

 GG

33

4.98 ± 0.74

1.25 (0.69)

1.93 ± 0.55

2.85 ± 0.68

1.40 ± 0.20

0.94 ± 0.21

1.56 ± 0.40

 F

–

0.661

2.381

0.327

0.685

0.434

0.959

0.893

 P

–

0.517

0.063

0.721

0.504

0.648

0.384

0.410

 CC + CG

588

4.88 ± 1.07

1.32 (0.84)

1.90 ± 0.48

2.72 ± 0.78

1.41 ± 0.28

0.90 ± 0.21

1.65 ± 0.52

 GG

33

4.98 ± 0.74

1.19 (0.69)

1.94 ± 0.55

2.85 ± 0.68

1.40 ± 0.20

0.94 ± 0.21

1.56 ± 0.40

 F

–

0.283

0.171

0.172

0.994

0.108

0.933

0.931

 P

–

0.595

0.679

0.678

0.318

0.742

0.334

0.335

Rs12563308

 TT

534

4.90 ± 1.08

1.42 (0.89)

1.91 ± 0.49

2.73 ± 0.79

1.42 ± 0.28

0.90 ± 0.21

1.64 ± 0.48

 CT

84

4.80 ± 0.87

1.21 (0.87)

1.86 ± 0.46

2.68 ± 0.72

1.38 ± 0.21

0.89 ± 0.20

1.66 ± 0.70

 CC

3

5.41 ± 0.83

1.17 (0.47)

1.99 ± 0.50

3.11 ± 1.05

1.43 ± 0.11

1.08 ± 0.26

1.39 ± 0.43

 F

–

0.842

0.466

0.450

0.553

0.826

1.260

0.409

 P

–

0.431

0.627

0.638

0.575

0.438

0.284

0.665

 TT

534

4.90 ± 1.09

1.42 (0.89)

1.91 ± 0.49

2.73 ± 0.79

1.42 ± 0.28

0.90 ± 0.21

1.64 ± 0.48

 CT + CC

87

4.80 ± 0.87

1.20 (0.86)

1.86 ± 0.46

2.69 ± 0.71

1.38 ± 0.20

0.89 ± 0.21

1.65 ± 0.69

 F

–

0.672

0.993

0.671

0.195

1.566

0.108

0.014

 P

–

0.413

0.334

0.413

0.659

0.211

0.742

0.906

  1. TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B. The value of triglyceride was presented as median (interquartile range), and the difference among the different genetic models was determined by Kruskal-Wallis test. A P < 0.025 was considered statistically significant after Bonferroni correction