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Table 1 Genes with significantly changed expression after simvastatin, FPP, and GGPP treatment of MiaPaCa-2 human pancreatic cancer cells

From: Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

 

Simva (S)

FPP (F)

Overlap (S) and (F)

Simva + FPP

GGPP

Simva + GGPP (SG)

Overlap (S) and (SG)

Upregulated genes (No.)

127

56

34

0

0

5

3

Downregulated genes (No.)

72

14

12

0

0

0

0

Differentially expressed genes (No.)

199

70

46

0

0

5

3

  1. Number of genes differentially transcribed between samples treated with simvastatin (12 μM), FPP (17 μM) or GGPP (17 μM) compared to control samples of untreated cells, as well as for each combination of simvastatin and an inhibitor. Only the transcripts with a minimally two-fold change in expression intensity and q < 0.05 were counted. See Fig. 2 and Additional file 1: Table S4 for more details
  2. Simva simvastatin, FPP farnesyl pyrophosphate, GGPP geranylgeranyl pyrophosphate
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Lipids in Health and Disease

ISSN: 1476-511X