Skip to main content

Table 4 Fatty acid composition of phospholipids in periuterine adipose tissue of Fischer 344 rats

From: Chemotherapy diminishes lipid storage capacity of adipose tissue in a preclinical model of colon cancer

Fatty acids (% total)

REF

TUM

1- Cycle 2-Cycles

C16:0

26.4 ± 1.4a

26.2 ± 2a

28.8 ± 1.3a

29.4 ± 1.4a

C16:1

3.0 ± 0.1a

1.6 ± 0.2b

1.4 ± 0.1 b

1.5 ± 0.2b

C18:0

22.3 ± 0.6a

30.3 ± 1.1b

29.2 ± 1.1b

30.1 ± 1.4b

C18:1

26.3 ± 1.4a

17.0 ± 1.5b

16.9 ± 1.5b

16.1 ± 1.2b

C18:2n6

13.4 ± 0.6a

12.4 ± 0.8a

12.2 ± 0.8a

11.6 ± 0.6a

C18:3n3

0.8 ± 0 a

0.2 ± 0b

0.2 ± 0.1b

0.2 ± 0b

C20:4n6

5.4 ± 0.6a

8.3 ± 0.7a

7.6 ± 0.5a

7.03 ± 0.5a

C20:5n3

0.1 ± 0a

NDa

NDa

NDa

C22:6n3

0.8 ± 0.1a

0.5 ± 0ab

0.3 ± 0b

0.3 ± 0b

ΣSFA

49.9 ± 1a

57.9 ± 2.3b

59.2 ± 1.8b

61 ± 1.9b

ΣMUFA

29.4 ± 1.3a

19.2 ± 1.6b

19.2 ± 1.6b

18.3 ± 1.4b

Σn-6/n-3

11.1 ± 0.5a

16.1 ± 0.5ab

21.0 ± 1.6b

18.6 ± 1.2b

Σn-6

18.9 ± 0.6a

21.5 ± 1.1a

20.6 ± 0.8a

19.5 ± 0.8a

Σn-3

1.7 ± 0.1a

1.3 ± 0.1ab

1.0 ± 0.1b

1.1 ± 0.1b

  1. Phospholipid fatty acids in periuterine adipose tissue of Fischer 344 rats bearing the Ward colorectal carcinoma receiving 1- or 2- cycles of chemotherapy. Healthy rats were used a reference for comparison (REF). Mean ± SEM, Kruskall test was used to determine significant differences between groups. Different superscripts (a, b) indicate significant differences between groups (P < 0.05); (n = 6–8/group). Abbreviations: SFA saturated fatty acids, MUFA monounsaturated fatty acids, PUFA polyunsaturated fatty acids; REF, Healthy, TUM Tumour-bearing, ND not determined