Feces and liver tissue metabonomics studies on the regulatory effect of aspirin eugenol eater in hyperlipidemic rats

Ma, Ning; Liu, Xiwang; Kong, Xiaojun; Li, Shihong; Jiao, Zenghua; Qin, Zhe; Dong, Pengcheng; Yang, Yajun; Li, Jianyong

doi:10.1186/s12944-017-0633-0

Lipids in Health and Disease

Table 2 Potential biomarkers in liver associated with AEE treatment based on UPLC-Q-TOF/MS analysis in hyperlipidemic rat

From: Feces and liver tissue metabonomics studies on the regulatory effect of aspirin eugenol eater in hyperlipidemic rats

NO.	RT	VIP	m/z	Formula	Metabolite	Trend
NO.	RT	VIP	m/z	Formula	Metabolite	M/C	AEE/M
1	1.11	2.33	118.0866	C₅H₁₁NO₂	Valine	↑^**	↑
2	1.73	2.46	137.0459	C₅H₄N₄O	Hypoxanthine	↑^**	↓^*
3	2.85	3.38	166.0857	C₉H₁₁NO₂	Phenylalanine	↓	↓^*
4	9.31	1.89	466.3179	C₂₆H₄₃NO₆	Glycocholic acid	↑	↑^**
5	12.12	2.76	524.3730	C₂₆H₅₄NO₇P	LysoPC (18:0)	↓	↓^**
6	13.63	2.92	568.3413	C₃₀H₅₀NO₇P	LysoPC (22:6)	↓^**	↓
7	13.81	6.30	544.3411	C₂₈H₅₀NO₇P	LysoPC (20:4)	↓^**	↓ ^*
8	14.83	2.087	400.3437	C₂₃H₄₅NO₄	Palmitoylcarnitine	↑^**	↓
9	16.91	2.15	428.3752	C₂₅H₄₉NO₄	Stearoylcarnitine	↑^**	↑
10	1.74	1.85	132.1017	C₆H₁₃NO₂	Isoleucine	↓^*	↑
11	3.41	1.44	220.1178	C₉H₁₇NO₅	Pantothenic acid	↓^**	↑
12	3.93	1.52	205.0971	C₁₁H₁₂N₂O₂	Tryptophan	↓	↓^**
13	10.32	1.82	318.301	C₁₈H₃₉NO₃	Phytosphingosine	↓^**	↑^**
14	11.08	1.81	450.3228	C₂₆H₄₃NO₅	GUDCA	↑	↑^**
15	13.35	1.36	494.3256	C₂₄H₄₈NO₇P	LysoPC (16:1)	↑^*	↑^**
16	14.04	1.41	424.3438	C₂₅H₄₅NO₄	Linoleyl carnitine	↑^**	↓
17	1.22	1.08	147.0767	C₅H₁₀N₂O₃	Glutamine	↑^**	↓
18	1.66	1.16	613.1611	C₂₀H₃₂N₆O₁₂S₂	Oxidized glutathione	↓	↑^**
19	1.67	1.13	123.0554	C₆H₆N₂O	Niacinamide	↑	↑^**
20	9.90	1.10	500.3053	C₂₆H₄₅NO₆S	TCDCA	↓^**	↑
21	14.14	1.26	542.3231	C₂₈H₄₈NO₇P	LysoPC (20:5)	↑	↓
22	15.16	3.23	546.3561	C₂₈H₅₂NO₇P	LysoPC (20:3)	↑^**	↓
23	1.75	2.10	267.0754	C₁₀H₁₂N₄O₅	Inosine	↑^**	↓^**
24	4.68	2.20	784.1549	C₂₇H₃₃N₉O₁₅P₂	FAD	↑^**	↓
25	16.66	2.42	327.2352	C₂₂H₃₂O₂	DHA	↓^*	↓
26	16.91	3.04	303.2348	C₂₀H₃₂O₂	Arachidonic acid	↓^*	↑
27	1.10	1.00	195.0525	C₆H₁₂O₇	Gluconic acid	↑^**	↓
28	4.59	1.01	686.1462	C₂₁H₃₅N₇O₁₃P₂S	Dephospho-CoA	↑	↓^**

M/C: model versus control; AEE/M: AEE versus model; ^* P < 0.05, ^** P < 0.01. GUDCA: Glycoursodeoxycholic acid; TCDCA: Taurochenodesoxycholic acid; DHA: Docosahexaenoic acid; FAD: flavine-adenine dinucleotide

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