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Table 1 Classification of progestogens

From: The effects of progesterones on blood lipids in hormone replacement therapy

Classification

Progestogen

Natural

Progesterone

Synthetic

Progestins

A. Structurally related to progesterone

  1. Pregnane derivatives

  a. acetylated (also called 17-hydroxyprogesterone derivatives): medroxyprogesterone acetate, megestrol acetate, cyproterone acetate, chlormadinone acetate

  b. nonacetylated: dydrogesterone, medrogestone

  2. 19-norpregnane derivatives (also called 19-norprogesterone derivatives)

  a. acetylated: nomegestrol acetate, nestorone

  b. nonacetylated: demegestone, trimegestone, promegestone

B. Structurally related to testosterone (also called 19-nortestosterone derivatives)

  1. ethinylated:

  a. estranes: norethindrone (also called norethisterone), norethindrone acetate, norethynodrel, lynestrenol, ethynodiol diacetate

  b. 18-ethylgonanes: levonorgestrel, norgestrel, desogestrel, gestodene, norgestimate

  2. nonethinylated: dienogest, drospirenone