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Table 5 Changes in lipid levels after dietary intervention over 16 weeks according to LPL rs320 genotypes

From: Apolipoprotein E gene polymorphism modifies fasting total cholesterol concentrations in response to replacement of dietary saturated with monounsaturated fatty acids in adults at moderate cardiovascular disease risk

 

SFA

 

MUFA

 

n-6 PUFA

 

Pinteraction

TT (N = 21)

G allele (N = 20)

Passociation

TT (N = 11)

G allele (N = 24)

Passociation

TT (N = 24)

G allele (N = 19)

Passociation

Total cholesterol

0.37 ± 0.60

0.29 ± 0.45

0.59

0.21 ± 2.66

−0.67 ± 2.07

0.21

−0.32 ± 1.67

−0.12 ± 0.64

0.92

0.34

TAG

−0.04 ± 2.35

0.07 ± 0.59

0.84

0.04 ± 0.50

0.01 ± 0.29

0.58

−0.07 ± 0.32

−1.19 ± 2.78

0.02

0.15

HDL-C

0.09 ± 0.15

0.01 ± 2.33

0.94

−0.07 ± 0.17

0.03 ± 0.15

0.04

0.02 ± 0.25

0.43 ± 2.91

0.78

0.75

LDL-C

0.29 ± 2.71

0.27 ± 0.40

0.95

−1.70 ± 2.85

0.16 ± 2.22

0.11

0.91 ± 2.23

−1.00 ± 2.50

0.007

0.005

  1. P values for association between genotypes and changes of means over 16 weeks with one of three diets were obtained by using general linear model adjusted for age, sex, body mass index, and ethnicity. P values for interaction between genotypes and changes of means over 16 weeks of intervention with one of three diets were obtained by using general linear model adjusted for age, sex, body mass index, and ethnicity. Values are mean ± SD
  2. TAG triacylglycerol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, SFA saturated fatty acids, MUFA monounsaturated fatty acids, PUFA polyunsaturated fatty acids