Skip to main content

Table 3 Baseline characteristics of the DIVAS study participants according to the LPL and APOE genotypes

From: Apolipoprotein E gene polymorphism modifies fasting total cholesterol concentrations in response to replacement of dietary saturated with monounsaturated fatty acids in adults at moderate cardiovascular disease risk

SNP

Age

Sex (M/F)

TAG (mmol/l)

HDL-C (mmol/l)

LDL-C (mmol/l)

Total cholesterol (mmol/l)

LPL

 rs320

  TT

46 ± 9

27/29

1.28 ± 0.63

1.54 ± 0.41

3.73 ± 0.96

5.52 ± 1.15

  T/G

48 ± 9

27/36

1.27 ± 0.57

1.53 ± 0.31

3.81 ± 1.01

5.59 ± 1.07

  P value

  

0.83

0.41

0.71

0.53

 rs328

  CC

46 ± 9

42/47

1.29 ± 0.63

1.52 ± 0.37

3.72 ± 1.01

5.49 ± 1.17

  C/G

48 ± 10

12/19

1.23 ± 0.47

1.58 ± 0.27

3.96 ± 0.88

5.79 ± 0.83

  P value

  

0.51

0.93

0.42

0.49

APOE

 rs405509

  GG

47 ± 10

17/14

1.41 ± 0.63

1.42 ± 0.39

3.71 ± 1.01

5.41 ± 1.20

  GT

47 ± 9

21/43

1.18 ± 0.57

1.58 ± 0.31

3.77 ± 1.00

5.58 ± 1.05

  TT

45 ± 11

16/9

1.34 ± 0.61

1.55 ± 0.38

3.85 ± 0.94

5.67 ± 1.12

   P value

  

0.57

0.24

0.81

0.70

 rs769450

  GG

47 ± 10

24/20

1.30 ± 0.61

1.57 ± 0.37

3.88 ± 0.96

5.71 ± 1.11

  G/A

46 ± 9

30/46

1.25 ± 0.59

1.51 ± 0.34

3.71 ± 1.00

5.47 ± 1.10

   P value

  

0.89

0.24

0.99

0.74

 rs439401

  CC

48 ± 9

25/25

1.37 ± 0.61

1.53 ± 0.36

3.88 ± 0.84

5.68 ± 0.95

  T allele

46 ± 10

29/39

1.22 ± 0.59

1.53 ± 0.34

3.69 ± 1.07

5.47 ± 1.19

   P value

  

0.43

0.95

0.54

0.54

 rs445925

  GG

46 ± 10

40/51

1.26 ± 0.58

1.53 ± 0.35

3.72 ± 1.00

5.50 ± 1.13

  A allele

49 ± 8

13/13

1.36 ± 0.67

1.56 ± 0.38

3.97 ± 1.00

5.80 ± 1.04

   P value

  

0.95

0.77

0.64

0.61

 rs405697

  GG

47 ± 9

35/35

1.32 ± 0.62

1.52 ± 0.39

3.77 ± 0.91

5.56 ± 1.01

  A allele

46 ± 10

19/30

1.22 ± 0.57

1.55 ± 0.31

3.77 ± 1.08

5.56 ± 1.22

   P value

  

0.77

0.91

0.95

0.95

 rs1160985

  CC

46 ± 11

17/16

1.24 ± 0.62

1.55 ± 0.34

3.73 ± 0.96

5.53 ± 1.11

  CT

47 ± 8

24/40

1.27 ± 0.61

1.57 ± 0.33

3.87 ± 0.96

5.69 ± 1.02

  TT

46 ± 11

13/10

1.35 ± 0.51

1.38 ± 0.40

3.57 ± 1.08

5.23 ± 1.30

   P value

  

0.98

0.58

0.51

0.49

 rs1064725

  TT

47 ± 9

48/60

1.26 ± 0.59

1.55 ± 0.34

3.79 ± 1.00

5.59 ± 1.11

  G allele

45 ± 10

6/6

1.40 ± 0.65

1.42 ± 0.46

3.60 ± 0.85

5.29 ± 1.00

   P value

  

0.39

0.32

0.79

0.65

  1. P values for association between genotypes and lipids levels were obtained by using general linear model adjusted for age, sex, body mass index, and ethnicity. Values are mean ± SD
  2. The dominant model was applied for all SNPs (rare homozygotes were grouped with heterozygotes and compared with common homozygotes), except SNPs rs405509 and rs1160985 where additive model was applied (common homozygotes vs. heterozygotes vs. rare homozygotes)
  3. TAG triacylglycerol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, LPL lipoprotein lipase, APOE apolipoprotein E
Back to article page

Lipids in Health and Disease

ISSN: 1476-511X