Fig. 4From: Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairmentSodium butyrate increased caspase activity in breast cancer cells. Cells were treated with sodium butyrate (5 and 10 mM) for 48 h and the activity of caspase 3 (a) and caspase 8 (b) was measured accordingly. The activity of caspase-8 was elevated in both cell lines. However, the caspase 3 activity was increased in MDA- MB-468 and remained unchanged in MCF-7 cells and MCF-10A cells. Data represent Mean ± SD of three separate experiments. Statistical differences between different groups were analyzed by ANOVA (* = P < 0.05, ** = P < 0.01, *** = P < 0.001)Back to article page