Isolated hypercholesterolemia leads to steatosis in the liver without affecting the pancreas

Table 2 Histological scores of the liver and pancreas of rats with isolated hypercholesterolemia

LIVER	Xanthomatous alteration	Steatotic microvesicles	Portal fibrosis	Kuppfer hyperplasia	Biliary proliferation	Lobular inflammation
Control	0.00 ± 0.00	0.25 ± 0.13	0.08 ± 0.08	0.17 ± 0.11	0.17 ± 0.11	0.33 ± 0.19
Chol	2.17 ± 0.24	1.08 ± 0.08	0.00 ± 0.00	0.00 ± 0.00	0.08 ± 0.08	0.08 ± 0.08
Significance	p < 0.05	p < 0.05	n.s.	n.s.	n.s.	n.s.
PANCREAS	Vacuolisation	Fatty infiltration	Relative number of islets	Islet deformations	Hemosiderin content of islets
Control	0.00 ± 0.00	0.00 ± 0.00	0.83 ± 0.40	1.00 ± 0.37	0.00 ± 0.00
Chol	0.17 ± 0.17	0.00 ± 0.00	0.67 ± 0.33	1.00 ± 0.52	0.00 ± 0.00
Significance	n.s.	n.s.	n.s.	n.s.	n.s.

Control: standard diet; Chol: 2% cholesterol and 0.25% cholic acid enriched diet for 12 weeks; n = 6–12

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