Groups | Food | Drug | Dosage | Concentration |
---|
Control | SRD | -- | -- | -- |
Model | HFD | -- | -- | -- |
CMC-Na | HFD | CMC-Na | 20 mg/kg | 5 mg/mL |
Statin | HFD | Simvastatin | 10 mg/kg | 2.5 mg/mL |
AEE Low | HFD | AEE | 18 mg/kg | 4.5 mg/mL |
AEE Mid | HFD | AEE | 36 mg/kg | 9 mg/mL |
AEE High | HFD | AEE | 54 mg/kg | 13.5 mg/mL |
- Rats were divided into seven groups. Control group was received SRD and the rest groups were received HFD, respectively. Based on the individual weekly body weight, rats were given with different drug suspension volume. CMC-Na as a vehicle was used in control group. Simvastatin was designed as positive drug. Different dose of three levels of AEE were administrated in the study. The administration period was 6 weeks and then blood lipids were analyzed
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AEE aspirin eugenol ester, SRD standard rat diet, HFD high fat diet