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Table 5 Haplotype frequency of FNDC5 variants in T2DM versus non-T2DM and obese versus lean subjects

From: SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects

Haplotype

T2DM

Control

Odd ratio (95 % CI)

P-value

Obese

Lean

Odd ratio (95 % CI)

P-value

AGAAG

119

125

1.00 (Reference)

95

73

1.00 (Reference)

AGAGG

87

99

0.93 (0.63–1.35)

0.681

65

61

0.82 (0.52–1.30)

0.398

GGAAG

27

28

1.01 (0.56–1.82)

0.966

8

27

0.23 (0.10–0.53)

0.001

GGAGG

9

14

0.68 (0.28–1.62)

0.379

11

6

1.41 (0.50–3.99)

0.519

GGGAG

45

50

0.95 (0.59–1.52)

0.817

32

32

0.77 (0.43–1.37)

0.371

GTAAT

39

45

0.91 (0.55–1.50)

0.711

33

27

0.94 (0.52–1.70)

0.836

GTAGT

47

39

1.27 (0.77–2.07)

0.349

29

30

0.74 (0.41–1.35)

0.327

GTGAG

3

5

0.63 (0.15–2.69)

0.533

4

3

1.02 (0.22–4.72)

0.975

  1. Note: Order of SNPs: rs3480A/G, rs1746661G/T, rs1298190A/G, rs726344A/G and rs1570569G/T). Pearson’s p value and OR (95 % CI) were calculated by haplotype analysis
  2. Bold means significant