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Table 1 Currently-known biological functions of miR-106b ~ 25 cluster

From: MiR-106b exhibits an anti-angiogenic function by inhibiting STAT3 expression in endothelial cells

microRNAs

Biological function

Target genes

References

miR-93

Preventing the progression of diabetic nephropathy

VEGF

[22]

miR-106b ~ 25

Inhibiting cell-cycle arrest and apoptosis

p21,Bim

[15, 23]

miR-106b

Impairing cellular cholesterol efflux and increasing the levels of secreted amyloid β

ABCA1

[24]

miR-106b,93

Inhibiting brown adipocyte differentiation

 

[25]

miR-106b ~ 25

Inhibiting apoptosis and promoting tube formation

PTEN

[16]

miR-25

Suppressing Cdk inhibitors and promoting cell proliferation

p57Kip2

[23]

miR-106b

Inhibiting cell cycle arrest and promoting cell proliferation

E2F1,E2F3

[26]

miR-106b

Activating p73 apoptotic signaling in Chronic Lymphocytic Leukemia cells

ITCH

[27]

miR-106b

Maintaining the structural homeostasis of developing lung epithelium

MAPK14,STAT3

[17]

miR-93

Inducing embryonic stem cell differentiation

STAT3

[28]