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Table 1 Time-dependent return of select biochemical parameters to normal concentrations following 1 month of poloxamer 407 administration to mice

From: Early-stage atherosclerosis in poloxamer 407-induced hyperlipidemic mice: pathological features and changes in the lipid composition of serum lipoprotein fractions and subfractions

Analyte

Control

P-4071 (24 h)

P-4071 (4 days)

P-4071 (10 days)

Total protein (g/l)

64.8 ± 11.1

**120 ± 4.7

61.2 ± 7.4

63.8 ± 0.9

Glucose (mg/dl)

79.5 ± 5.8

82.9 ± 5.0

*54.0 ± 2.2

66.7 ± 3.8

ALT (U/l)

37.8 ± 4.5

*50.1 ± 4.7

28.5 ± 1.9

29.1 ± 1.1

AST (U/l)

144 ± 11.3

146 ± 14.3

152 ± 9.0

165 ± 17.4

  1. 1Times indicate the time period following the discontinuation of P-407 administration for 1 month
  2. *p < 0.05
  3. **p < 0.01 vs. control