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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Early-stage atherosclerosis in poloxamer 407-induced hyperlipidemic mice: pathological features and changes in the lipid composition of serum lipoprotein fractions and subfractions

Fig. 5

Light microscopic findings of liver (a, b, c) and heart (d, e, f) of mice following prolonged (1 mo) administration of poloxamer 407. All specimens were stained with hematoxylin and eosin at the magnification indicated. а Liver of control mice, 400 X. b Liver of mice 4 days after discontinuation of P-407 administration. Hepatocytes and macrophages exhibited ‘foamy’ cytoplasm, 400 X. с Liver of mice 10 days after discontinuation of P-407 administration. Increased number of ‘foamy’ macrophages are visible, which appear to be localized in sinusoids and in the periportal zone, 400 X. d Myocardium of control mice, 200 X. e Myocardium of mice 24 h after discontinuation of P-407 administration. Swollen vessel walls of the muscle-elastic type are visible, together with localized changes of contracture-type cardiomyocytes shown with arrows, 400 X. f Myocardium of mice 24 h after discontinuation P-407 administration. Perivascular edema in the walls of blood vessel in interstitial tissue with groups of cells overloaded with lipids (arrow), 400 X

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Lipids in Health and Disease

ISSN: 1476-511X