A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice

Table 7 Effects of FSC-S and FSC-SpEt supplementation on food, water and drug intake in normal and experimental hypercholesterolemic (HCL) mice

Groups	Drug dose (%, w/w)	Food intake (g/kg/day)	RFBW	FEI	Water intake (ml/kg/day)	RWBW	WEI	Drug intake (g/kg/day)
Normal mice
ND	–	176.74	1.56	3.95	310.90	2.94	7.44	–
ND/FSC-S	9	130.09	1.28	9.21	222.57	2.01	14.50	12.73
ND/FSC-SpEt	9	169.48	1.66	4.24	276.40	1.06	6.29	16.76
ND/FF	0.05	167.29	1.49	4.03	287.38	2.56	6.92	0.08
HCL mice
ND	–	184.89	1.67	5.78	269.88	2.44	8.44	–
HCBD	–	174.75	1.57	5.53	271.64	2.47	8.68	–
HCBD/FSC-S	3	165.93	1.57	5.33	257.95	2.37	8.04	5.13
	9	129.31	1.28	7.36	236.87	2.14	12.27	12.79
HCBD/FSC-SpEt	3	176.02	1.67	5.72	271.91	2.50	8.57	5.44
	9	181.26	1.83	6.75	244.30	2.24	8.28	17.93
HCBD/FF	0.05	192.56	1.81	6.63	265.16	2.49	9.13	0.10

Experimental details were described in Table 1. Mice were fed with ND and HCBD without or with FSC-S, FSC-SpEt, or FF supplementation for 10 days. During supplementation, the volumes of food/water/drug intake and the ratio of food/water intake to body weight were estimated in each group. The dosages of drug intake (g/kg/day) were determined by noting the amount of ingested diet (g/kg/day) and the drug concentrations in the diet. The weight of drug was subtracted from the food intake. FSC-S and FSC-SpEt doses were based on their crude herbal material. The ratio of food (g) and water (mL) intake to body weight (g) (RFBW and RWBW, respectively) was calculated by using the formula as follow: total food (g) and water (mL) intake divided total body weight (g) for an experimental period of 10 days. The feed efficiency index (FEI) and water efficiency index (WEI) was calculated by using the formula as follow: food (g) and water (mL) consumption divided body weight gain (g) for the 10 days of treatment with drugs

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