Groups | Drug dose (%, w/w) | Stomach | Residual gastric content | Fecal TC (μmol/g) | ||||
---|---|---|---|---|---|---|---|---|
Weight (g) | Index 1 | Index 2 | Weight (g) | Index 1 | Index 2 | |||
Normal mice | Â | Â | Â | Â | Â | Â | Â | Â |
ND | – | 0.34 ± 0.02 | 1.18 ± 0.06 | 1.26 ± 0.06 | 0.55 ± 0.06 | 1.92 ± 0.20 | 2.05 ± 0.21 | 5.91 ± 0.22 |
ND/FSC-S | 9 | 0.25 ± 0.02** | 1.25 ± 0.06 | 1.38 ± 0.07 | 0.73 ± 0.06* | 3.59 ± 0.20** | 3.97 ± 0.23** | 5.21 ± 0.57 |
ND/FSC-SpEt | 9 | 0.32 ± 0.01 | 1.12 ± 0.03 | 1.20 ± 0.03 | 0.45 ± 0.05 | 1.59 ± 0.19 | 1.70 ± 0.20 | 4.82 ± 0.29** |
ND/FF | 0.05 | 0.28 ± 0.02* | 1.02 ± 0.05* | 1.31 ± 0.06 | 0.42 ± 0.03 | 1.53 ± 0.10 | 1.70 ± 0.11 | 6.72 ± 0.40 |
HCL mice | Â | Â | Â | Â | Â | Â | Â | Â |
ND | – | 0.31 ± 0.01 | 1.06 ± 0.03 | 1.13 ± 0.03 | 0.61 ± 0.09 | 2.06 ± 0.26 | 2.20 ± 0.28 | 5.24 ± 0.47 |
HCBD | – | 0.30 ± 0.01 | 1.05 ± 0.03 | 1.12 ± 0.03 | 0.53 ± 0.06 | 1.82 ± 0.20 | 1.96 ± 0.22 | 23.18 ± 1.00** |
HCBD/FSC-S | 3 | 0.29 ± 0.01 | 0.99 ± 0.04 | 1.08 ± 0.04 | 0.49 ± 0.09 | 1.70 ± 0.32 | 1.88 ± 0.37 | 23.72 ± 0.80 |
 | 9 | 0.28 ± 0.01 | 1.12 ± 0.04 | 1.26 ± 0.04# | 0.66 ± 0.08 | 2.57 ± 0.27# | 2.91 ± 0.31# | 20.86 ± 1.06 |
HCBD/FSC-SpEt | 3 | 0.31 ± 0.02 | 1.08 ± 0.06 | 1.16 ± 0.06 | 0.36 ± 0.02# | 1.27 ± 0.07# | 1.37 ± 0.08# | 25.43 ± 1.72 |
 | 9 | 0.30 ± 0.01 | 1.07 ± 0.04 | 1.15 ± 0.04 | 0.41 ± 0.04# | 1.41 ± 0.12 | 1.53 ± 0.13 | 24.87 ± 0.96 |
HCBD/FF | 0.05 | 0.31 ± 0.01 | 1.10 ± 0.04 | 1.25 ± 0.04# | 0.37 ± 0.04# | 1.29 ± 0.11# | 1.47 ± 0.12 | 27.84 ± 1.19## |