A comparative study between Wuweizi seed and its post-ethanol extraction residue in normal and hypercholesterolemic mice

Table 1 Effects of FSC-S and FSC-SpEt supplementation on serum lipid profiles and GLU in normal and experimental hypercholesterolemic (HCL) mice

Groups	Dose	TC	TG	HDL	LDL	HDL/LDL	LDL/HDL	N-HDL	GLU
Groups	(%, w/w)	(mmol/L)	(mmol/L)	(mmol/L)	(mmol/L)	HDL/LDL	LDL/HDL	(mmol/L)	(mmol/L)
Normal mice
ND	-	3.58 ± 0.17	1.42 ± 0.21	2.41 ± 0.05	0.30 ± 0.01	8.06 ± 0.32	0.13 ± 0.01	1.17 ± 0.15	10.29 ± 0.50
ND/FSC-S	9	5.87 ± 0.34^**	3.62 ± 0.31^**	4.06 ± 0.11^**	0.48 ± 0.02^**	8.74 ± 0.50	0.12 ± 0.01	1.80 ± 0.37	7.03 ± 0.48^**
ND/FSC-SpEt	9	4.46 ± 0.16^**	1.22 ± 0.09	2.58 ± 0.09	0.38 ± 0.01^**	6.86 ± 0.22^**	0.15 ± 0.01^**	1.87 ± 0.14^**	11.47 ± 0.29
ND/FF	0.05	3.66 ± 0.30	0.79 ± 0.04^*	2.36 ± 0.07	0.33 ± 0.02	7.40 ± 0.45	0.14 ± 0.01	1.29 ± 0.28	10.96 ± 0.41
HCL mice
ND	-	4.31 ± 0.15	1.29 ± 0.04	2.96 ± 0.15	0.36 ± 0.03	8.67 ± 0.54	0.12 ± 0.01	1.35 ± 0.10	8.14 ± 0.36
HCBD	-	5.74 ± 0.19^**	0.99 ± 0.04^**	3.00 ± 0.08	1.50 ± 0.07^**	2.05 ± 0.13^**	0.50 ± 0.02^**	2.73 ± 0.15^**	8.00 ± 0.19
HCBD/FSC-S	3	6.98 ± 0.32^##	1.23 ± 0.12	3.72 ± 0.14^##	2.22 ± 0.08^##	1.68 ± 0.05^#	0.60 ± 0.02^##	3.26 ± 0.21	7.78 ± 0.28
	9	9.41 ± 0.55^##	2.16 ± 0.29^##	5.30 ± 0.24^##	3.11 ± 0.23^##	1.76 ± 0.10	0.59 ± 0.04	4.11 ± 0.50^#	7.01 ± 0.48
HCBD/FSC-SpEt	3	5.96 ± 0.27	0.73 ± 0.03^##	3.25 ± 0.10	1.51 ± 0.09	2.34 ± 0.18	0.47 ± 0.03	2.71 ± 0.24	8.33 ± 0.55
	9	5.91 ± 0.16	0.84 ± 0.05^#	3.65 ± 0.18^##	1.50 ± 0.09	2.49 ± 0.12^#	0.41 ± 0.02^#	2.26 ± 0.16^#	8.43 ± 0.26
HCBD/FF	0.05	4.03 ± 0.16^##	0.78 ± 0.04^##	2.37 ± 0.08^##	0.67 ± 0.06^##	3.80 ± 0.39^##	0.28 ± 0.02^##	1.66 ± 0.15^##	7.69 ± 0.30

Mice were fed with normal diet (ND) or high cholesterol/bile salt (1/0.3 %, w/w) diet (HCBD) to establish a model of mouse hypercholesterolemia (HCL). Fructus Schisandrae Chinensis seed (FSC-S) and post-ethanol extraction residue of FSC-S (FSC-SpEt) were smashed to pass through the 60 mesh sieve and mixed with either ND or HCBD at the indicated doses, which were estimated on the basis of crude herbal material. Fenofibrate (FF) was adopted as a positive control for comparison. Ten days after dietary supplementation, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), non-HDL (N-HDL), and glucose (GLU) levels, as well as HDL/LDL and LDL/HDL ratio were measured. Values given are the means ± SEM, with n = 10. ^* P < 0.05, ^** P < 0.01 vs ND; ^# P < 0.05, ^## P < 0.01 vs HCBD. Statistical significant differences were determined using a one-way ANOVA followed by Dunnett’s multiple comparisons test or post-hoc analysis

ISSN: 1476-511X