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Table 1 Phospholipid fatty acid profile of control and ALA-treated BT-474 cells. Results are presented as molar % of total fatty acids. N = 6

From: α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways

 

Control

ALA

14:0

2.03 ± 0.62

1.27 ± 1.08

16:0

28.95 ± 4.94

27.16 ± 4.68

18:0

18.11 ± 3.14

17.95 ± 2.62

20:0

0.94 ± 0.21

0.56 ± 0.13

22:0

0.10 ± 0.03a

1.14 ± 0.10b

16:1 n-7

6.97 ± 2.86

6.24 ± 3.55

18:1n-9

16.45 ± 1.03

11.74 ± 1.62

18:1n-7

4.36 ± 0.18a

2.68 ± 0.34b

20:1n-9

0.32 ± 0.08

0.05 ± 0.02

22:1n-9

1.35 ± 0.70a

0.53 ± 0.20b

18:2n-6

4.68 ± 0.86

3.11 ± 0.42

18:3n-6

1.95 ± 0.92

1.15 ± 0.29

20:2n-6

0.35 ± 0.05a

0.18 ± 0.03b

20:4n-6

6.34 ± 0.63a

2.83 ± 0.79b

22:4n-6

0.38 ± 0.05a

0.14 ± 0.02b

22:5n-6

0.08 ± 0.04

0.04 ± 0.01

18:3n-3

0.39 ± 0.15a

19.60 ± 3.60b

20:3n-3

2.64 ± 0.22a

1.09 ± 0.10b

20:5n-3

1.29 ± 0.81

1.14 ± 0.19

22:5n-3

1.18 ± 0.06

0.84 ± 0.17

22:6n-3

1.15 ± 0.12a

0.55 ± 0.14b

n-6:n-3

2.09 ± 0.08a

0.34 ± 0.07b

  1. *values with different superscripts in the same row are significantly different by unpaired T-test