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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Lipid changes within the epidermis of living skin equivalents observed across a time-course by MALDI-MS imaging and profiling

Fig. 3

a MALDI-MSI-IMS image mapping the in-source fragment m/z ion species for SM (d18:1/16:0) in tissue and within a SM (d18:1/16:0) lipid standard. Particularly m/z 520.5024 is likely to be the N-paltimitoylsphingosine unit of the structure following neutral loss of cyclophosphane [H (HO)P (O) (OCH2CH2O)] m/z 183. The ion m/z 644.4309 correspond to a loss of trimethylamineN (Ch3) m/z 59 from the M + H adduct. Ion map for m/z 256.2599 represents the d18 side chain of the SM lipid structure. The approximate fragment conformations are depicted in the structural diagram. b. MALDI-MSI-IMS of commonly occurring fragment ions found within tissue and lipid standards representative of fatty acyl side chains

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