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Table 5 Enrichment analysis based on the number of predicted functional partners of FGA indicated by STRING analysis

From: Fibrinogen production is enhanced in an in-vitro model of non-alcoholic fatty liver disease: an isolated risk factor for cardiovascular events?

GO term

Description

P-value

FDR q-value

Enrichment (N, B, n, b)

GO:0030168

Platelet activation

1.43E-05

1.96E-02

3.00 (33,11,8,8)

GO:0051592

Response to calcium ion

1.83E-04

1.26E-01

11.00 (33,3,3,3)

GO:0050817

Coagulation

3.02E-04

1.38E-01

1.55 (33,16,20,15)

GO:0007599

Chemostasis

3.02E-04

1.04E-01

1.55 (33,16,20,15)

GO:0007596

Blood coagulation

3.02E-04

8.30E-02

1.55 (33,16,20,15)

GO:0001775

Cell activation

4.88E-04

1.12E-01

2.36 (33,14,8,8)

GO:0006887

Exocytosis

5.88E-04

1.15E-01

2.89 (33,10,8,7)

GO:0002576

Platelet degranulation

5.88E-04

1.01E-01

2.89 (33,10,8,7)

GO:0032940

Secretion by cell

5.88E-04

8.96E-02

2.89 (33,10,8,7)

  1. Enrichment was calculated as (b/n) / (B/N), where N is the total number of partners including FGA; B is the total number of genes associated with a specific GO term; n is the number of genes in the STRING partner list, as ranked by confidence score or in the target set when appropriate b is the number of genes in the intersection.