Skip to main content

Table 1 ApoE isoform amino acid differences and resulting chemical and physiological changes (according to Mahley and Rall [2], Minihane et al. [7])

From: Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review

Isoform

Amino acid 112

Amino acid 158

Relative charge

Lipoprotein preference

LDL receptor binding affinity

apoE2

cysteine

cysteine

0

HDL

low

apoE3

cysteine

arginine

+1

HDL

high

apoE4

arginine

arginine

+2

VLDL, chylomicrons

high

  1. HDL: high density lipoprotein, VLDL: very low density lipoprotein