From: Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review
Isoform | Amino acid 112 | Amino acid 158 | Relative charge | Lipoprotein preference | LDL receptor binding affinity |
---|---|---|---|---|---|
apoE2 | cysteine | cysteine | 0 | HDL | low |
apoE3 | cysteine | arginine | +1 | HDL | high |
apoE4 | arginine | arginine | +2 | VLDL, chylomicrons | high |